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Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome

  • Glaucoma
  • Published:
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Abstract

Purpose

We aimed to evaluate the serum prolidase activity (SPA), malondialdehyde (MDA), and catalase levels in patients with pseudoexfoliation (PEX) syndrome.

Method

Thirty-four patients with PEX syndrome and thirty-eight age- and gender-matched healthy subjects were included in this prospective clinical study. Each participant underwent full ophthalmologic examination. The SPA, serum MDA, and catalase levels were measured and compared between the patients with PEX syndrome and healthy subjects.

Results

The SPA was significantly lower in patients with PEX syndrome compared to healthy controls (14.1 ± 7.1 vs. 30.1 ± 4.3 ng/ml; p = 0.001). The mean serum MDA values the of PEX syndrome and control groups were comparable (28.7 ± 5.7 vs. 30.4 ± 5.3 nmol/ml, respectively; p = 0.185). The mean serum catalase level tended to be lower in the PEX group compared to healthy controls (0.12 ± 0.02 vs. 0.21 ± 0.05 k/ml, respectively; p = 0.077).

Conclusion

Our findings suggest that the SPA was significantly lower in patients with PEX syndrome compared to healthy controls. Thus, prolidase may have a role in the pathogenesis of the PEX syndrome.

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Authors and Affiliations

  1. Department of Ophthalmology, Dumlupinar University School of Medicine, Kutahya, 43270, Turkey

    Mehmet Tetikoğlu, Haci Murat Sağdik, Serdar Aktas & Fatih Özcura

  2. Department of Biochemistry, Dışkapı Yıldırım Beyazit Training and Research Hospital, Ankara, Turkey

    Fatma Uçar

Authors
  1. Mehmet Tetikoğlu
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  2. Haci Murat Sağdik
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  3. Serdar Aktas
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  4. Fatma Uçar
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  5. Fatih Özcura
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Corresponding author

Correspondence to Mehmet Tetikoğlu.

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Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

The study adhered to the tenets of the Declaration of Helsinki. The Institutional Review Board of the Dumlupinar University School of Medicine approved the study protocol.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

This manuscript has not been previously published and is not under consideration for publication elsewhere. The authors do not have any financial or proprietary interest in a product, method, or material mentioned in the manuscript.

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Tetikoğlu, M., Sağdik, H.M., Aktas, S. et al. Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 254, 1339–1343 (2016). https://doi.org/10.1007/s00417-016-3338-6

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  • DOI: https://doi.org/10.1007/s00417-016-3338-6

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