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Canaloplasty in patients with uveitic glaucoma: a pilot study

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Glaucoma is a common vision-threatening complication of uveitis. We investigated the outcome of canaloplasty in patients with chronic uveitis and uncontrolled secondary glaucoma.

Methods

This was a retrospective study of 12 patients with medically uncontrolled secondary glaucoma who underwent canaloplasty (14 treated eyes), with follow-up of ≥ 24 months. The primary outcome measure was complete and qualified (requirement for anti-glaucomatous medication) surgical success rates, as determined by a reduction in intraocular pressure (IOP) and the need for anti-glaucomatous medication. Secondary outcome measures were uveitis activity, best-corrected visual acuity (BCVA), vision-threatening complications, and secondary glaucoma surgery.

Results

Canaloplasty resulted in a significant IOP reduction, from a mean preoperative baseline level of 27.1 ± 12.3 mmHg to a mean of 14.5 ± 4.3 mmHg (p = 0.01) at 24 months. Complete success (limit of 15 mmHg) was achieved in six patients and qualified success in one patient. However, failure was noted in five patients, two of whom required additional glaucoma surgery. Topical anti-glaucomatous medications were reduced from 2.7 ± 1.2 (mean ± SD) at baseline to 0.6 ± 1.2 at 24 months (p = 0.007). Uveitis activity did not increase after surgery. BCVA was not reduced; cataract progressed in two patients.

Conclusion

At 2-year follow-up, overall success rate was 58 % (IOP ≤ 15 with or without medication), and surgery failed in 5 eyes, 2 eyes requiring additional glaucoma surgery. No harmful complications or worsening of uveitis activity were noted.

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Authors and Affiliations

  1. Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany

    Claudia Lommatzsch, Carsten Heinz, Arnd Heiligenhaus & Joerg Michael Koch

  2. University of Duisburg-Essen, Essen, Germany

    Carsten Heinz & Arnd Heiligenhaus

  3. Department of Experimental Ophthalmology, University of Muenster, Muenster, Germany

    Arnd Heiligenhaus

Authors
  1. Claudia Lommatzsch
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  2. Carsten Heinz
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  3. Arnd Heiligenhaus
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  4. Joerg Michael Koch
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Corresponding author

Correspondence to Claudia Lommatzsch.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; or expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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No funding was received for this research.

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Lommatzsch, C., Heinz, C., Heiligenhaus, A. et al. Canaloplasty in patients with uveitic glaucoma: a pilot study. Graefes Arch Clin Exp Ophthalmol 254, 1325–1330 (2016). https://doi.org/10.1007/s00417-016-3325-y

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  • DOI: https://doi.org/10.1007/s00417-016-3325-y

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