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Evaluation of structural contributors in myopic eyes of preterm and full-term children

  • Medical Ophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

We conducted a cross-sectional study to test the hypothesis that the structural contributions to myopia in preterm and full-term born children are different.

Methods

In this study, 93 children ranging from ages 2 to 13 who had myopia ≥ −3 diopters in at least one eye were examined with A-scans. The following data was collected and analyzed: history of birth, refractive error (RE), cornea thickness (CT) and average corneal curvature (AVK), depth of anterior chamber (ACD), lens thickness (LT), and axial length (AL) of the eye.

Results

Eyes were tested and categorized into four groups: myopic eyes in full-term children (group 1), myopic eyes in premature children (group 2), non-myopic eyes in full-term children (group 3), and non-myopic eyes in preterm children (group 4). The RE were similar between group 1 and group2, and between group 3 and group 4. Myopic eyes in group 2 had higher AVK as compared to group 3; 45.4 ± 0.4 D vs. 43.5 ± 0.7 D, p = 0.008. The ACD in group 2 was shallower than that in group 1 (2.5 ± 0.5 vs. 3.2 ± 0.3, p = 0.01). The LT measurements in group 2 were thicker than those in group 1 (mean LT = 4.9 ± 1.0 vs 4.1 ± 0.3 mm, p = 0.001, respectively). Finally, AL of myopic eyes in group 1 was longer than that of group 2, p = 0.01.

Conclusion

These results suggest that increased axial length plays an important role in myopia in full-term children, whereas corneal curvature and lens thickness are major contributors to myopia in preterm children.

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Authors and Affiliations

  1. Department of Ophthalmology, Baylor College of Medicine, 6701 Fannin St, Suite 610.25, Houston, TX, 77030, USA

    Saira Bhatti, Evelyn A. Paysse, Mitch P. Weikert & Lingkun Kong

Authors
  1. Saira Bhatti
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  2. Evelyn A. Paysse
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  3. Mitch P. Weikert
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  4. Lingkun Kong
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Corresponding author

Correspondence to Lingkun Kong.

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Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Funding

No funding was received for this research.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Bhatti, S., Paysse, E.A., Weikert, M.P. et al. Evaluation of structural contributors in myopic eyes of preterm and full-term children. Graefes Arch Clin Exp Ophthalmol 254, 957–962 (2016). https://doi.org/10.1007/s00417-016-3307-0

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  • DOI: https://doi.org/10.1007/s00417-016-3307-0

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