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Pulse waveform analysis in the optic nerve head circulation reflects systemic vascular resistance obtained via a Swan–Ganz catheter

  • Neurophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether a pulse waveform analysis in the optic nerve head (ONH) circulation as determined by laser speckle flowgraphy (LSFG) can provide systemic hemodynamic values — the systemic vascular resistance (SVR) in particular — similar to those obtained by using a Swan–Ganz catheter, which is an invasive method.

Method

Sixteen consecutive subjects were examined. Hemodynamic monitoring was obtained from right heart catheterization with a Swan–Ganz catheter and coronary angiography without an intracoronary nitroglycerin administration. Direct blood pressure was measured with a trans-radial approach. Single regression analyses were used to determine the relationship between the blowout score and blowout time, which are the items of the pulse waveform analysis in the ONH, by using LSFG and the hemodynamic parameters.

Results

The blowout time was significantly and negatively correlated with the SVR (r = −0.52, p = 0.04), the ocular perfusion pressure with the mean arterial blood pressure of the radial artery (r = −0.52, p = 0.04) and the radial artery pulse pressure (r = −0.52, p = 0.04).The pulmonary capillary wedge pressure (r  = −0.44, p = 0.09) and the mean arterial blood pressure of the radial artery (r  = −0.44, p = 0.09) tended to be correlated with the blowout time, but did not reach significance. The blowout score was significantly and negatively correlated with the radial artery blood pressure (r = −0.51, p = 0.046).

Conclusion

A pulse waveform analysis in the ONH by LSFG may be one of the useful methods for understanding the SVR.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Tomoaki Shiba, Tadashi Matsumoto & Yuichi Hori

  2. Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan

    Mao Takahashi

  3. Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan

    Ryuya Hashimoto

Authors
  1. Tomoaki Shiba
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  2. Mao Takahashi
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  3. Ryuya Hashimoto
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  4. Tadashi Matsumoto
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  5. Yuichi Hori
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Corresponding author

Correspondence to Tomoaki Shiba.

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No funding was received for this research.

Conflicts of interest

The authors have no proprietary or financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in in any aspect of this report.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Shiba, T., Takahashi, M., Hashimoto, R. et al. Pulse waveform analysis in the optic nerve head circulation reflects systemic vascular resistance obtained via a Swan–Ganz catheter. Graefes Arch Clin Exp Ophthalmol 254, 1195–1200 (2016). https://doi.org/10.1007/s00417-016-3289-y

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  • DOI: https://doi.org/10.1007/s00417-016-3289-y

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