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Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment

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Abstract

Purpose

The aim of this study was to determine the changes in the luminal and stromal areas of the choroid in eyes with Vogt-Koyanagi-Harada disease by optical coherence tomography (OCT).

Methods

A retrospective observational study. Choroidal images were recorded by enhanced depth imaging (EDI-OCT) at the baseline, and at 1 week and 1 month after initiating steroid therapy. The EDI-OCT images were converted to binarized images, and the luminal areas and the stromal areas were measured separately.

Results

Thirty-two eyes of 16 patients were enrolled, and 16 eyes of 10 patients had suitable images for the binarization analyses. The ratio of the luminal areas to the choroidal areas was 0.60 ± 0.03 at the baseline, 0.67 ± 0.04 at 1 week, and 0.66 ± 0.04 at 1 month. There was a significant increase from the baseline at 1 week (P < 0.01) but not from 1 week to 1 month. Although both the stromal and luminal areas were reduced, the percent reduction of the stromal areas (56.5 ± 7.2 %) was significantly greater than that of the luminal areas (42.5 ± 12.6 %) at 1 week (P < 0.01).

Conclusions

A significant decrease of the choroidal area was detected in eyes with Vogt-Koyanagi-Harada disease at 1 week after beginning steroid therapy. The decrease was more evident in the stromal area than in the luminal area.

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Acknowledgments

The authors thank Prof. Duco Hamasaki, Miami University, for his critical discussion and editing of the final manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan

    Hiroki Kawano, Shozo Sonoda, Takehiro Yamashita & Taiji Sakamoto

  2. Department of Ophthalmology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Ichiro Maruko & Tomohiro Iida

Authors
  1. Hiroki Kawano
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  2. Shozo Sonoda
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  3. Takehiro Yamashita
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  4. Ichiro Maruko
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  5. Tomohiro Iida
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  6. Taiji Sakamoto
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Corresponding author

Correspondence to Taiji Sakamoto.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers’ bureaus, membership, employment, consultancies, stock ownership, or other equity interest, and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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Kawano, H., Sonoda, S., Yamashita, T. et al. Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment. Graefes Arch Clin Exp Ophthalmol 254, 421–426 (2016). https://doi.org/10.1007/s00417-016-3283-4

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  • DOI: https://doi.org/10.1007/s00417-016-3283-4

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