Abstract
Purpose
The purpose of this study was to evaluate the regression of neovascularization elsewhere (NVE) after panretinal photocoagulation (PRP) based on its location in relation to the internal limiting membrane (ILM).
Methods
Participants in this retrospective case series were 47 patients with active NVE within the vascular arcade. All patients were treated with PRP and followed up for at least 12 months. The time to regression of NVE based on its location relative to the ILM on spectral domain-optical coherence tomography (SD-OCT) was analyzed.
Results
The proportion of eyes, showing regression of NVE at the end of follow-up period was 19/25 (76 %) in the “below ILM” group and 13/22 (59 %) in the “above ILM” group. The “below ILM” group was associated with a twofold enhanced regression of NVE in comparison to the “above ILM” group (HR = 2.13, p = 0.038).
Conclusions
Regression of NVE is determined by its location relative to the ILM. Patients with “below ILM” NVE were found to show a twofold increased regression rate in comparison with the “above ILM” group, while the proportion of eyes showing regression of NVE at the end of the follow-up period was significantly greater in the “below ILM” than the “above ILM” group.
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Irini Chatziralli and Theodoros Sergentanis certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, or other equity interest), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. Sobha Sivaprasad has received research grants, attended Advisory Board meetings of Allergan, Bayer and Novartis.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Institutional review board approval is not required in our institute for retrospective studies.
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Chatziralli, I.P., Sergentanis, T.N. & Sivaprasad, S. Prediction of regression of retinal neovascularisation after panretinal photocoagulation for proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 254, 1715–1721 (2016). https://doi.org/10.1007/s00417-016-3275-4
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DOI: https://doi.org/10.1007/s00417-016-3275-4