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Determinants of pupil diameters and pupil dynamics in an adult Chinese population

  • Glaucoma
  • Published:
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Abstract

Background

To investigate the determinants of pupil diameter (PD), amplitude of pupil diameter change (PD-change) and speed of pupil constriction (SPC) using video anterior segment optical coherence tomography (AS-OCT) in a population-based sample of Chinese adults.

Methods

Chinese adults aged 40 to 80 years who were free from glaucoma were consecutively recruited from the population-based Singapore Chinese Eye Study. The SPC was measured by AS-OCT videography. Univariate and multivariate analyses were performed to examine the effects of demographic and ocular biometric factors (e.g., axial length [AL], anterior chamber depth [ACD], baseline PD, iris thickness at the area of the dilator muscle [ITDMR], iris area [IA], and iris bowing [IB]) on SPC, PD, and PD-change.

Results

A total of 266/302 (89.5 %) AS-OCT videos of eligible eyes were available for analysis. Among these subjects, 64.3 % were women, and the mean age (± standard deviation [SD]) was 56 ± 8.3 years. SPC was not associated with sex. In multiple regression analyses, SPC was independently associated with baseline PD (β = 0.116, p = 0.006). Baseline PD was independently associated with ACD (β = 0.341, p < 0.001), TISA 500 (β = −4.513, p < 0.001), IA (β = −2.796, p < 0.001), and ITDMR (β = 6.573, p < 0.001). PD-change was independently associated with ACD (β = 0.256, p < 0.001), IA (β = −1.507, p < 0.001), IB (β = 0.630, p = 0.011), and ITDMR (β = 3.124, p < 0.001).

Conclusions

Among normal eyes in an adult Chinese population, SPC was associated with larger baseline PD. Larger baseline PD and greater PD change form dark to light were associated with greater ACD, with smaller IA and thicker ITDMR.

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Authors and Affiliations

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Correspondence to Tin Aung.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Funding

Financial support in the form of grant funding was provided by the National Medical Research Council, Singapore, and the National Research Foundation, Singapore.

The sponsor had no role in the design or conduct of this research.

Conflict of interest

Dr. T. Aung has received research funding, travel support, and honoraria from Carl Zeiss Meditec. Dr. Perera has received honoraria from Carl Zeiss Meditec. The remaining authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; or expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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Video 1

AS-OCT videography showing pupillary constriction in response to illumination (AVI 7.55 mb)

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Zheng, C., de Leon, J.M.S., Cheung, C.Y. et al. Determinants of pupil diameters and pupil dynamics in an adult Chinese population. Graefes Arch Clin Exp Ophthalmol 254, 929–936 (2016). https://doi.org/10.1007/s00417-016-3272-7

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  • DOI: https://doi.org/10.1007/s00417-016-3272-7

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