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A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”)

  • Oncology
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Abstract

Purpose

The purpose was to illustrate small melanocytic choroidal tumors with speckle-noise free swept-source optical coherence tomography (SSOCT).

Methods

Twenty-five small melanocytic choroidal tumors in 24 eyes underwent 1050 nm OCT. All tumors were measured manually with the built-in caliper tool and compared to data derived from a semiautomated algorithm that removed speckle noise but preserved the structure of the tumors from the SSOCT data.

Results

The average manual measurements for the horizontal, vertical, and axial diameters were 1535.28 μm (range, 547–2807 μm), 1713.8 μm (range, 574–3921 μm), and 227.28 μm (range, 115–489 μm), respectively. The measured average volumes of the tumors were 835,248,212 μm3 (range, 48,818,700 to 4,567,401,810 μm3) and 228,588,535 μm3 (range, 22,879,641 to 787,668,886 μm3) for caliper measurements, respectively, for the extracted volumes. The average volume variation between the two methods was 66.16 % (range, 46.5 % to 82.75 %). The average ratio between the caliper and extracted volumes was 3.402 (range, 1.346–8.198, SD 1.681), 2.367 (range, 1.346–3.258, SD 0.618), 2.321 (range, 1.346–3.258, SD 0.611), 2.402 (range, 1.518–3.258, SD 0.591), and 1.749 (range, 1.518–1.733, SD 0.239) for all tumors, all tumors with the exclusion of extreme parameters, tumor <3 mm, tumor <2 mm, and tumor <1 mm, respectively. The average ratio (tumor index) between the tumor volume and the choroidal vessel volume was 12.539 (range, 0.489–73.701).

Conclusion

Speckle-noise free swept-source OCT may be an illustrative OCT imaging technology. OCT may be useful for describing and monitoring small melanocytic choroidal tumors and the choroidal vessels.

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Authors and Affiliations

  1. Department of Ophthalmology, OCTlab, University of Basel, Mittlere Strasse 91, CH-4056, Basel, Switzerland

    Peter Maloca, Cyrill Gyger & Pascal Willy Hasler

Authors
  1. Peter Maloca
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  2. Cyrill Gyger
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  3. Pascal Willy Hasler
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Corresponding author

Correspondence to Peter Maloca.

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Funding

No funding was received for this research.

Conflict of interest

Peter Maloca and Cyrill Gyger are owners of the intellectual property of the speckle-noise analysis technology discussed in this manuscript. Peter Maloca and Pascal Hasler are consultants and have received lecture fees from Mediconsult/Topcon and Optos. The funding organizations had no role in the design or conduct of the current study. All authors certify that, except as indicated above, they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Maloca, P., Gyger, C. & Hasler, P.W. A pilot study to compartmentalize small melanocytic choroidal tumors and choroidal vessels with speckle-noise free 1050 nm swept source optical coherence tomography (OCT choroidal “tumoropsy”). Graefes Arch Clin Exp Ophthalmol 254, 1211–1219 (2016). https://doi.org/10.1007/s00417-016-3270-9

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  • DOI: https://doi.org/10.1007/s00417-016-3270-9

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