Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients

  • Young Gun Park
  • Jae Ryun Kim
  • Seungbum Kang
  • Eric Seifert
  • Dirk Theisen-Kunde
  • Ralf Brinkmann
  • Young-Jung RohEmail author
Retinal Disorders



Selective retina therapy (SRT) stimulates retinal pigment epithelium (RPE) cell migration and proliferation into irradiated areas. The objective of this study was to evaluate the efficacy and safety of SRT in Korean patients with clinically significant diabetic macular edema (DME).


Prospective non-randomized interventional case series study. Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 6 months. Patients underwent an evaluation of best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure macular sensitivity within the central 10° field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured.


An improvement in BCVA of one to two ETDRS lines was observed in 41.2 % of patients and an improvement of greater than two lines in 29.4 %. Although there was no significant change in CMT (P > 0.05), MMT decreased from 465.8 ± 87.4 μm to 434.3 ± 83.9 μm (P = 0.006), and mean macular sensitivity increased from 20.8 ± 3.4dB to 22.5 ± 3.5dB (P = 0.02).


The gains in BCVA and improvement in macular sensitivity demonstrated that SRT may be used as an effective and safe treatment modality in Korean patients with clinically significant DME.


Diabetic macular edema Dosimetry Microperimetry Selective retina therapy Retinal pigment epithelium 



No author has financial or proprietary interests in any material or method mentioned.

This study was supported by the South Korean government-affiliated Ministry of Trade, Industry and Energy (M000004912-00192937). The sponsor had no role in the design or conduct of this research.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Young Gun Park
    • 1
  • Jae Ryun Kim
    • 1
  • Seungbum Kang
    • 1
  • Eric Seifert
    • 2
  • Dirk Theisen-Kunde
    • 2
  • Ralf Brinkmann
    • 2
  • Young-Jung Roh
    • 1
    • 3
    Email author
  1. 1.Department of Ophthalmology and Visual ScienceCatholic University of KoreaSeoulRepublic of Korea
  2. 2.Medical Laser Center Lübeck GmbHLübeckGermany
  3. 3.Department of Ophthalmology, Yeouido St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

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