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Influence of optic disc leakage on objective optic nerve head assessment in patients with uveitis

  • Inflammatory Disorders
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Abstract

Purpose

Secondary glaucoma is a common complication in patients with uveitis. Heidelberg Retina Tomography (HRT) and retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT) are widely used for examining optic nerve head changes. We evaluated these parameters in patients with uveitis and secondary glaucoma and with inflammatory papillary leakage on fluorescein angiography.

Methods

Prospective single-center analysis of patients with uveitis, evaluating the impact of optic disc leakage on objective optic disc imaging parameters.

Results

Overall, 96 eyes of 59 patients were included. Papillary leakage was found in 42 eyes (43.8 %), and secondary glaucoma was found in 41 eyes (42.7 %). Glaucoma and papillary leakage were present in 12 (29 %) eyes with leakage and in 29 (54 %) eyes without leakage (p = 0.023). Neuroretinal rim area (p = 0.004), rim volume on HRT (p = 0.004), and RNFL thickness on OCT (p = 0.0008) were significantly increased in eyes with papillary leakage, while RNFL on HRT was unchanged (p = 0.255). When only eyes with normal IOP were examined, all objective parameters on OCT and HRT were significantly increased, whereas in eyes with secondary glaucoma, there was only a trend in the same direction, which did not reach significance. A comparison of eyes with secondary glaucoma and optic disc leakage to normal eyes with no glaucoma or leakage revealed no difference in any of the parameters.

Conclusions

The objective parameters of optic nerve head imaging tools are significantly influenced by papillary leakage. In patients with secondary glaucoma and papillary leakage, these techniques are unable to detect and monitor glaucomatous damage.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, St. Franziskus-Hospital Muenster, Hohenzollernring 74, 48145, Muenster, Germany

    Carsten Heinz, Katy Kogelboom & Arnd Heiligenhaus

  2. Department of Ophthalmology, University of Duisburg- Essen, Essen, Germany

    Carsten Heinz & Arnd Heiligenhaus

Authors
  1. Carsten Heinz
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  2. Katy Kogelboom
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  3. Arnd Heiligenhaus
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Corresponding author

Correspondence to Carsten Heinz.

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Funding

No funding was received for this research.

Conflict of Interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Trial Registration: NCT01170481

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Heinz, C., Kogelboom, K. & Heiligenhaus, A. Influence of optic disc leakage on objective optic nerve head assessment in patients with uveitis. Graefes Arch Clin Exp Ophthalmol 254, 361–364 (2016). https://doi.org/10.1007/s00417-015-3218-5

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  • DOI: https://doi.org/10.1007/s00417-015-3218-5

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