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Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy

Graefe's Archive for Clinical and Experimental Ophthalmology volume 254, pages 977–981 (2016)Cite this article

Abstract

Purpose

The purpose of this study was to evaluate systemic endothelial function in elderly hypertension patients with non-arteritic anterior ischaemic optic neuropathy (NAION) by using a noninvasive physiological method: endothelium-dependent, flow-mediated vasodilation (FMD).

Methods

Forty-two systemic hypertension patients with NAION (NAION group), 64 age- and sex-matched patients with systemic hypertension and no other ocular disease (hypertension group), and 100 age- and sex-matched healthy volunteers (normal group) were enrolled. FMD was evaluated using a high-resolution ultrasonography. Traditional cardiovascular risk factors and vascular parameters were measured.

Results

Systolic blood pressure and diastolic blood pressure were significantly higher in patients with NAION compared with the control groups (p < 0.001). The FMD decreased significantly in the NAION group (6.02 ± 1.87 %) compared to in the hypertension group (7.86 ± 2.94 %, p < 0.001) and the normal group (8.99 ± 2.44 %, p < 0.001). By multivariable logistic regression analysis, FMD was significantly associated with NAION (OR, 1.79; 95%CI, 1.67–2.01).

Conclusions

NAION may be associated with systemic vascular endothelial dysfunction. FMD might be useful in the treatment monitoring of NAION.

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References

  1. Hayreh SS, Podhajsky P, Zimmerman MB (1999) Role of nocturnal arterial hypotension in optic nerve head ischemic disorders. Ophthalmologica 213:76–96

    CAS  Article  PubMed  Google Scholar 

  2. Newman NJ, Scherer R, Langenberg P et al (2002) The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study. Am J Ophthalmol 134:317–328

    Article  PubMed  Google Scholar 

  3. Atkins EJ, Bruce BB, Newman NJ, Biousse V (2010) Treatment of nonarteritic anterior ischemic optic neuropathy. Surv Ophthalmol 55:47–63

    Article  PubMed  PubMed Central  Google Scholar 

  4. Flaharty PM, Sergott RC, Lieb W, Bosley TM, Savino PJ (1993) Optic nerve sheath decompression may improve blood flow in anterior ischemic optic neuropathy. Ophthalmology 100:297–302

    CAS  Article  PubMed  Google Scholar 

  5. Hayreh SS, Joos KM, Podhajsky PA, Long CR (1994) Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 118:766–780

    CAS  Article  PubMed  Google Scholar 

  6. Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115:1285–1295

    PubMed  Google Scholar 

  7. Nadar S, Blann AD, Lip GY (2004) Endothelial dysfunction: methods of assessment and application to hypertension. Curr Pharm Des 10:3591–3605

    CAS  Article  PubMed  Google Scholar 

  8. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE (1994) Endothelium dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24:1468–1474

    CAS  Article  PubMed  Google Scholar 

  9. Celermajer DS, Sorensen KE, Gooch VM et al (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111–1115

    CAS  Article  PubMed  Google Scholar 

  10. Corretti MC, Anderson TJ, Benjamin EJ et al (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39:257–265

    Article  PubMed  Google Scholar 

  11. Moens AL, Goovaerts I, Claeys MJ, Vrints CJ (2005) Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 127:2254–2263

    Article  PubMed  Google Scholar 

  12. Benjamin EJ, Larson MG, Keyes MJ et al (2004) Clinical correlates and heritability of flow-mediated dilation in the community: Framingham heart study. Circulation 109:613–619

    Article  PubMed  Google Scholar 

  13. Juonala M, Viikari JS, Laitinen T et al (2004) Interrelations between brachial endothelial function and carotid intimamedia thickness in young adults: the cardiovascular risk in young Finns study. Circulation 110:2918–2923

    Article  PubMed  Google Scholar 

  14. Suwaidi JA, Hamasaki S, Higano ST et al (2000) Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101:948–954

    CAS  Article  PubMed  Google Scholar 

  15. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104:2673–2678

    CAS  Article  PubMed  Google Scholar 

  16. Halcox JP, Schenke WH, Zalos G et al (2002) Prognostic value of coronary vascular endothelial dysfunction. Circulation 106:653–658

    Article  PubMed  Google Scholar 

  17. Santos-García D, Blanco M, Serena J et al (2009) Brachial arterial flow mediated dilation in acute ischemic stroke. Eur J Neurol 16:684–690

    Article  PubMed  Google Scholar 

  18. Su WW, Cheng ST, Ho WJ et al (2008) Glaucoma is associated with peripheral vascular endothelial dysfunction. Ophthalmology 115:1173–1178

    Article  PubMed  Google Scholar 

  19. Fadini GP, Pagano C, Baesso I et al (2010) Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma. Acta Ophthalmol 88:135–141

    Article  PubMed  Google Scholar 

  20. Sogawa K, Nagaoka T, Tanano I et al (2012) Association between diabetic retinopathy and flow-mediated vasodilation in type 2 DM. Curr Eye Res 37:446–451

    CAS  Article  PubMed  Google Scholar 

  21. Tanano I, Nagaoka T, Sogawa K et al (2013) Impaired Systemic Vascular Endothelial Function in Patients with Branch Retinal Vein Occlusion. Curr Eye Res 38:114

    Article  PubMed  Google Scholar 

  22. Pemp B, Weigert G, Karl K et al (2009) Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers. Diabetes Care 32:1536–1541

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  23. Nguyen TT, Islam FM, Farouque HM et al (2010) Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke 41:1343–1348

    Article  PubMed  PubMed Central  Google Scholar 

  24. Potarazu SV (1997) Ischemic optic neuropathy: models for mechanism of disease. Clin Neurosci 4:264–269

    CAS  PubMed  Google Scholar 

  25. Sakai T, Shikishima K, Matsushima M, Tsuneoka H (2013) Genetic polymorphisms associated with endothelial function in nonarteritic anterior ischemic optic neuropathy. Mol Vis 19:213–219

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Sakai T, Shikishima K, Matsushima M, Kitahara K (2007) Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 245:288–292

    CAS  Article  PubMed  Google Scholar 

  27. Miyamoto M, Kotani K, Ishibashi S, Taniguchi N (2012) The effect of antihypertensive drugs on endothelial function as assessed by flow-mediatedvasodilation in hypertensive patients. Int J Vasc Med 2012:453264

    PubMed  PubMed Central  Google Scholar 

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Author information

Affiliations

  1. Department of Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 510080

    Fengjuan Yao

  2. Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080

    Pengxia Wan, Yihua Su, Ruiduan Liao & Wenhui Zhu

Authors
  1. Fengjuan Yao
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  2. Pengxia Wan
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  3. Yihua Su
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  4. Ruiduan Liao
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  5. Wenhui Zhu
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Corresponding author

Correspondence to Wenhui Zhu.

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Funding

The Department of Science and Technology of Guangdong Province provided financial support in the form of 2014A020212578 funding. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Yao, F., Wan, P., Su, Y. et al. Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 254, 977–981 (2016). https://doi.org/10.1007/s00417-015-3212-y

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  • DOI: https://doi.org/10.1007/s00417-015-3212-y

Keywords

  • Non-arteritic anterior ischaemic optic neuropathy
  • Endothelial function
  • Nitric oxide
  • Vasodilation
  • Doppler sonography