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Structural dissociation of optic disc margin components with optic disc tilting: a spectral domain optical coherence tomography study

  • Glaucoma
  • Published:
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Abstract

Purpose

To investigate the dissociation of the Bruch’s membrane opening (BMO) from the scleral canal opening (SO) of the optic disc.

Methods

In this prospective, cross-sectional, observational study, 101 eyes from 101 patients or suspected subjects of primary open angle glaucoma were included. Enhanced depth imaging spectral domain optical coherence tomography images along the long axis of the optic disc were used to visualize better the deep structures around the optic disc on both the temporal and nasal sides. The distances between the BMO and SO were measured at the temporal and nasal sides of the optic disc, and their correlations with age, axial length, intraocular pressure, disc size, disc ovality index, disc torsion degree, and visual field mean deviation were investigated.

Results

The temporal and nasal distances of BMO from SO correlated significantly with each other (R = 0.632, P < 0.0001). By multiple linear regression analysis, significant correlations were found for disc ovality index (temporal: β = −0.691, P < 0.0001; nasal: β = −0.420, P < 0.0001) and axial length (temporal: β = 0.224, P = 0.002; nasal: β = 0.310, P = 0.001). The other factors did not show any significant correlation.

Conclusion

Locations of the SO at not only the temporal, but also the nasal side of the optic disc are nasally shifted from the BMO with optic disc tilting and axial length elongation in glaucomatous eyes, and are significantly correlated to each other. The nasal shift of the deep structures of the optic disc should be considered especially when assessing myopic eyes with optic disc tilt.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Tomoko Hasegawa, Tadamichi Akagi, Masanori Hangai, Hiroshi Yamada, Kenji Suda, Yugo Kimura, Hideo Nakanishi, Hanako Ohashi Ikeda & Nagahisa Yoshimura

  2. Department of Ophthalmology, Saitama Medical University, Saitama, Japan

    Masanori Hangai

  3. Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan

    Hanako Ohashi Ikeda

Authors
  1. Tomoko Hasegawa
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  2. Tadamichi Akagi
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  3. Masanori Hangai
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  4. Hiroshi Yamada
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  5. Kenji Suda
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  6. Yugo Kimura
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  7. Hideo Nakanishi
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  8. Hanako Ohashi Ikeda
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  9. Nagahisa Yoshimura
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Corresponding author

Correspondence to Tadamichi Akagi.

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Funding

The Ministry of Education, Culture, Sports, Science, and Technology (MEXT) in Japan provided financial support in the form of Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems. The Japan Society for the Promotion of Science (JSPS) also provided financial support in the form of Grant-in-Aid for Scientific Research (25462713). The sponsors had no role in the design or conduct of this research. No funding was received for this research.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study adhered to the tenets of the 1964 Declaration of Helsinki its later amendments, and the study was approved by the Institutional Review Board and the Ethics Committee of Kyoto University Graduate School of Medicine.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Electronic supplementary material

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Fig. S1

Correlations between the temporal and nasal Bruch’s membrane opening (BMO)-scleral canal opening (SO) distances and the visual field mean deviation (MD) values. Both the temporal (a) and nasal (b) BMO-SO distances did not correlate with the MD values (a: R = −0.063, P = 0.542; b: R = −0.013, P = 0.901) (GIF 28 kb)

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Hasegawa, T., Akagi, T., Hangai, M. et al. Structural dissociation of optic disc margin components with optic disc tilting: a spectral domain optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 254, 343–349 (2016). https://doi.org/10.1007/s00417-015-3210-0

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  • DOI: https://doi.org/10.1007/s00417-015-3210-0

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