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Interpretation of fundus autofluorescence changes in choriocapillaritis: a multi-modality imaging study

  • Retinal Disorders
  • Published:
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Abstract

Purpose

We aimed to describe imaging findings in primary inflammatory choriocapillaropathies (PICCPs) after a photobleaching process.

Methods

2Images from six consecutive cases of patients affected by PICCPs (four with multiple evanescent white dot syndrome and two with multifocal choroiditis) were reviewed. Patients underwent fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and spectral-domain optical coherence tomography (SD-OCT) by means of the Spectralis HRA (Heidelberg Engineering, Heidelberg, Germany). FAF images were acquired at the beginning of the examination in partially dark-adapted conditions followed by light adapted conditions.

Results

During the active phase of the diseases, all patients showed areas of increased FAF that became isoautofluorescent after photobleaching. Simultaneously with increased FAF, the ICGA showed typical hypofluorescent dark areas that were more evident in the late phase. SD-OCT showed disruptions in the hyper-reflective band at the ellipsoid zone.

Conclusions

FAF and SD-OCT are complementary imaging techniques that show alterations in the outer retina of patients affected by PICCPs.

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Author information

Authors and Affiliations

  1. Ophthalmology Unit, Ospedale Valduce, Como, Italy

    Alessandro Mantovani

  2. Eye Clinic Department of Clinical Science “Luigi Sacco”, Luigi Sacco Hospital University of Milan, via G.B. Grassi, 74 - 20157, Milan, Italy

    Andrea Giani & Giovanni Staurenghi

  3. Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care & University of Lausanne, Lausanne, Switzerland

    Carl P. Herbort Jr

Authors
  1. Alessandro Mantovani
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  2. Andrea Giani
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  3. Carl P. Herbort Jr
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  4. Giovanni Staurenghi
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Corresponding author

Correspondence to Giovanni Staurenghi.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Mantovani, A., Giani, A., Herbort, C.P. et al. Interpretation of fundus autofluorescence changes in choriocapillaritis: a multi-modality imaging study. Graefes Arch Clin Exp Ophthalmol 254, 1473–1479 (2016). https://doi.org/10.1007/s00417-015-3205-x

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  • DOI: https://doi.org/10.1007/s00417-015-3205-x

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