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Recurrence of macular edema in eyes with branch retinal vein occlusion changes the diameter of unaffected retinal vessels

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To measure unaffected retinal vessel diameter in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after intravitreal injection with bevacizumab (IVB).

Methods

Patients with BRVO-induced ME who responded to IVB were assessed at baseline and 1, 3, and 6 months. In both eyes, the diameters of the largest arteriole and venule in all quadrants (except occlusion quadrant) were measured by using a computer-assisted method. The same vessels chosen at baseline were measured at each follow-up examination.

Results

Forty-two eyes were participated. At baseline, venular diameters of unaffected quadrants in eyes with BRVO were larger than the venules in the corresponding quadrant of the fellow eyes (p < 0.05, respectively). The venular diameters in all quadrants of the affected eyes decreased significantly relative to baseline after IVB (p < 0.05 respectively). Twenty-two eyes (52.4 %) developed recurrent ME. On recurrence at 3 (n = 15, 35.7 %) or 6 months (n = 7, 16.7 %), the unaffected venular diameters increased significantly (p < 0.05 respectively). These diameters again decreased significantly after a second IVB (p < 0.05 respectively).

Conclusion

Unaffected retinal venular diameters associate with the course of BRVO with ME. This may help elucidate the pathological mechanism underlying BRVO.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2014R1A1A2055007), and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (A111345). The authors are grateful to Professor Nicola Ferrier and Dr. Amitha Domalpally (University of Wisconsin–Madison) for generously providing the IVAN analysis program.

Funding

Ministry of Education provided financial support in the form of the Basic Science Research Program through the National Research Foundation of Korea (NRF) (NRF-2014R1A1A2055007). Ministry of Health & Welfare provided financial support in the form of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) (A111345). The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea

    Jong Chan Im, Jae Pil Shin, In Taek Kim & Dong Ho Park

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  1. Jong Chan Im
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  2. Jae Pil Shin
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Correspondence to Dong Ho Park.

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Im, J.C., Shin, J.P., Kim, I.T. et al. Recurrence of macular edema in eyes with branch retinal vein occlusion changes the diameter of unaffected retinal vessels. Graefes Arch Clin Exp Ophthalmol 254, 1267–1274 (2016). https://doi.org/10.1007/s00417-015-3175-z

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  • DOI: https://doi.org/10.1007/s00417-015-3175-z

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