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Detecting ultrasonographic hollowness in small choroidal melanocytic tumors using 10 MHz and 20 MHz ultrasonography: a comparative study

  • Oncology
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Abstract

Background

The purpose of this work was to compare the detection of ultrasonographic hollowness (UH), as a risk sign for evolution from small choroidal melanocytic tumors (SCMT) to uveal melanoma (UM), between conventional ultrasonography (standardized 8 MHz ultrasonography and B-mode 10 MHz ultrasonography) and high-resolution 20 MHz ultrasonography.

Methods

Fifty SCMTs from 50 eyes were included in this work. In all cases, ultrasonographic studies were performed using: 8 MHz standardized A-mode, 10 MHz B-mode, and posterior pole 20 MHz B-mode. Comparison between the presence and the absence of UH were carried out between the ultrasonographic images.

Results

There were no statistically significant differences between the SCMT dimensions obtained using the 8–10 and 20 MHz techniques. UH was detected in 12 and 20 cases by means of ten and 20 MHz probes respectively. The difference between these proportions was statistically different from zero (McNemar test, p-value = 0.008). Cases without UH by 20 MHz have lower height values than cases with UH. However, these differences were not found by 10 MHz ultrasonography. By receiver operating characteristic (ROC) study, specificity was better by 20 MHz than 10 MHz ultrasonography when the value of tumor height as marker for UH was studied.

Conclusions

UH is easier to detect by 20 MHz than by 10 MHz ultrasonography. This ultrasonographic sign appears to be correlated with the height of the tumor. Thus, we believe UH estimation by 20 MHz ultrasonography could be used as a significant predictive factor for SCMT growth.

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References

  1. Collaborative Ocular Melanoma Study Group (2006) Twelve-year mortality rates and prognostic factors. Randomized trial of iodine 125 brachytherapy for choroidal melanoma. COMS report no. 28. Arch Ophthalmol 124:1684–1693

    Article  Google Scholar 

  2. Diener-West M, Reynolds SM, Agugliaro DJ et al (2005) Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group, report no. 26. Arch Ophthalmol 123:1639–1643

    Article  PubMed  Google Scholar 

  3. Augsburger JJ, Schroeder RP, Territo C et al (1989) Clinical parameters predictive of enlargement of melanocytic lesions. Br J Ophthalmol 73:911–917

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Shields CL, Shields JA, Kiratli H et al (1995) Risk factors for growth and metastasis of small choroidal melanocytic lesions. Ophthalmology 102:1351–1361

    Article  CAS  PubMed  Google Scholar 

  5. Shields CL, Cater J, Shields JA et al (2000) Combination of clinical factors predictive of growth of small choroidal melanocytic tumors. Arch Ophthalmol 118:360–364

    Article  CAS  PubMed  Google Scholar 

  6. Shields CL, Furuta M, Berman EL et al (2009) Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases. Arch Ophthalmol 127:981–987

    Article  PubMed  Google Scholar 

  7. Collaborative Ocular Melanoma Study Group (1997) Factors predictive of growth and treatment of small choroidal melanoma. COMS report no. 5. Arch Ophthalmol 115:1537–1544

    Article  Google Scholar 

  8. Singh AD, Kalyani P, Topham A (2005) Estimating the risk of malignant transformation of a choroidal nevus. Ophthalmology 112:1784–1789

    Article  PubMed  Google Scholar 

  9. Singh AD, Mokashi AA, Bena JF, Jacques R, Rundle PA, Rennie IG (2006) Small choroidal melanocytic lesions: features predictive of growth. Ophthalmology 113:1032–1039

    Article  PubMed  Google Scholar 

  10. Ossoinig KC, Lohmeyer M (1990) Choroidal nevi: diagnosis with standardized echography. In: Sampaolesi R (ed) Ultrasonography in ophthalmology, 12th edn. Kluwer, Dordrecht, p 173

    Chapter  Google Scholar 

  11. Minning CA Jr, Davidrof FH (1982) Ossoinig’s angle of ultrasonic absorption and its role in the diagnosis of malignant melanoma. Ann Ophthalmol 14:564–568

    PubMed  Google Scholar 

  12. Collaborative Ocular Melanoma Study Group (2003) Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the Collaborative Ocular Melanoma Study. COMS report no. 21. Arch Ophthalmol 121:1163–1171

    Article  Google Scholar 

  13. Byrne SF, Marsh MJ, Boldt HC, Green RL, Johnson RN, Wilson DJ (2002) Consistency of observations from echograms made centrally in the Collaborative Ocular Melanoma Study. Ophthalmic Epidemiol 9:11–27

    Article  PubMed  Google Scholar 

  14. Collaborative Ocular Melanoma Study (1999) Echography (ultrasound) procedures for the Collaborative Ocular Melanoma Study (COMS), report no. 12, part II. J Ophthalmic Nurs Technol 18:219–232

    Google Scholar 

  15. Collaborative Ocular Melanoma Study (1999) Echography (ultrasound) procedures for the Collaborative Ocular Melanoma Study (COMS), report no. 12, part I. J Ophthalmic Nurs Technol 18:143–149

    Google Scholar 

  16. Berson M, Grégoire JM, Gens F et al (1999) High frequency (20 MHz) ultrasonic devices: advantages and applications. Eur J Ultrasound 10:53–63

    Article  CAS  PubMed  Google Scholar 

  17. Hewick SA, Fairhead AC, Culy JC, Atta HR (2004) A comparison of 10 MHz and 20 MHz ultrasound probes in imaging the eye and orbit. Br J Ophthalmol 88:551–555

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Coleman DJ, Silverman RH, Chabi A et al (2004) High-resolution ultrasonic imaging of the posterior segment. Ophthalmology 111:1344–1351

    Article  PubMed  Google Scholar 

  19. Ossoinig KC (1979) Standardized echography: basic principles, clinical applications, and results. Int Ophthalmol Clin 19:127–210

    Article  CAS  PubMed  Google Scholar 

  20. Ossoinig KC, Bigar F, Kaefring SL (1975) Malignant melanoma of the choroid and ciliary body: a differential diagnosis in clinical echography. Bibl Ophthalmol 83:141–154

    PubMed  Google Scholar 

  21. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310

    Article  CAS  PubMed  Google Scholar 

  22. R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria. URL: http://www.R-project.org/. Accessed 15 Jan 2014

  23. Frazier Byrne S, Green RL (2002) Intraocular tumors. In: Frazier Byrne S, Green RL (eds) Ultrasound of the eye and orbit, 2nd edn. Mosby, St. Louis, pp 115–190

    Google Scholar 

  24. Kook D, Kreutzer TC, Wolf A, Haritoglou C (2011) Variability of standardized echographic ultrasound using 10 MHz and high-resolution 20 MHz B scan in measuring intraocular melanoma. Clin Ophthalmol 5:477–482

    Article  PubMed Central  PubMed  Google Scholar 

  25. Goldberg MF, Hodes BL (1977) Ultrasonographic diagnosis of choroidal malignant melanoma. Surv Ophthalmol 22:29–40

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Surgical Retina and Ocular Oncology Unit, Servizo de Oftalmoloxía, Hospital de Conxo, Complexo Hospitalario de Santiago, c/Ramón Baltar s/n, 15706, Santiago de Compostela, Spain

    Antonio Piñeiro-Ces, María Santiago, Manuel Bande, Carmela Capeáns & María José Blanco

  2. Department of Statistics and Operational Research, University of Vigo, Vigo, Spain

    María José Rodríguez Alvarez

  3. Grupo Obesidómica, Laboratorio de Endocrinología Molecular y Celular, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain

    María Pardo

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  1. Antonio Piñeiro-Ces
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  2. María José Rodríguez Alvarez
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  3. María Santiago
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  4. Manuel Bande
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  5. María Pardo
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  6. Carmela Capeáns
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  7. María José Blanco
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Correspondence to Antonio Piñeiro-Ces.

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Piñeiro-Ces, A., Rodríguez Alvarez, M.J., Santiago, M. et al. Detecting ultrasonographic hollowness in small choroidal melanocytic tumors using 10 MHz and 20 MHz ultrasonography: a comparative study. Graefes Arch Clin Exp Ophthalmol 252, 2005–2011 (2014). https://doi.org/10.1007/s00417-014-2758-4

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  • DOI: https://doi.org/10.1007/s00417-014-2758-4

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