Skip to main content

Advertisement

SpringerLink
Log in

Photoreceptor inner and outer segment layer thickness in multiple evanescent white dot syndrome

  • Medical Ophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the photoreceptor inner and outer segment layer thickness in eyes with MEWDS.

Design

Prospective, non-comparative, observational case series. The follow-up duration was 4 months.

Methods

Four women were diagnosed with unilateral MEWDS. The ages of the patients were 25, 24, 35, and 40 years. The retinal microstructure was assessed by spectral-domain optical coherence tomography (SD-OCT). The thickness of the photoreceptor inner (IS) and outer (OS) segments and sum of them (IS + OS) at the fovea were analyzed.

Results

The visual acuity was reduced in three of four eyes at the acute phase. SD-OCT showed that the border of IS and OS (IS/OS) line and the cone outer segment tips (COST) line in the macula area were not detected in all four eyes. The IS + OS thickness was 50.3 ± 5.6 μm and that of the healthy fellow eyes was 73.5 ± 7.0 μm (n = 4 eyes). The thickness of the IS was 27.8 ± 2.6 μm and that of the OS was 45.8 ± 7.3 μm. In all eyes, there was a spontaneous improvement of the visual acuity. SD-OCT showed a recovery of only the IS/OS line in the macular area, but the COST line was not visible in three cases. The mean IS + OS thickness increased to 56.0 ± 7.9 μm (n = 4), IS = 26.0 ± 2.0 μm (n = 3), and OS = 30.1 ± 8.7 μm (n = 3) in the early recovery phase, and to 64.8 ± 9.3 μm (n = 4), IS = 28.5 ± 1.7 μm (n = 4), and OS = 36.3 ± 7.9 μm (n = 4) in the late recovery phase. The mean inner and outer segment thickness remained unchanged in the fellow eyes.

Conclusion

Eyes with MEWDS have changes in the photoreceptor microstructures. The change in the IS + OS thickness during the natural recovery course might be due to an increase in the OS length.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Jampol LM, Sieving PA, Pugh D, Fishman GA, Gilbert H (1984) Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol 102:671–674

    Article  PubMed  CAS  Google Scholar 

  2. Sieving PA, Fishman GA, Jampol LM, Pugh D (1984) Multiple evanescent white dot syndrome. II. Electrophysiology of the photoreceptors during retinal pigment epithelial disease. Arch Ophthalmol 102:675–679

    Article  PubMed  CAS  Google Scholar 

  3. Li D, Kishi S (2009) Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome. Ophthalmology 116:762–770

    Article  PubMed  Google Scholar 

  4. Nguyen MH, Witkin AJ, Reichel E, Ko TH, Fujimoto JG, Schuman JS, Duker JS (2007) Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography. Retina 27:414–418

    Article  PubMed  PubMed Central  Google Scholar 

  5. Spaide RF, Koizumi H, Freund KB (2008) Photoreceptor outer segment abnormalities as a cause of blind spot enlargement in acute zonal occult outer retinopathy-complex diseases. Am J Ophthalmol 146:111–120

    Article  PubMed  Google Scholar 

  6. Forooghian F, Stetson PF, Gross NE, Meyerle CB (2010) Quantitative assessment of photoreceptor recovery in atypical multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging 41(Suppl):S77–S80

    Article  Google Scholar 

  7. Gross NE, Yannuzzi LA, Freund KB, Spaide RF, Amato GP, Sigal R (2006) Multiple evanescent white dot syndrome. Arch Ophthalmol 124:493–500

    Article  PubMed  Google Scholar 

  8. Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M, Bach M (2009) International society for clinical electrophysiology of vision. ISCEV standard for full-field clinical electroretinography (2008 update). Doc Ophthalmol 118:69–77

    Article  PubMed  CAS  Google Scholar 

  9. Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) International society for clinical electrophysiology of vision. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 124:1–13

    Article  PubMed  Google Scholar 

  10. Yannuzzi LA (2010) Inflammation. In: The retinal atlas. Elsevier, New York, pp 238–245

    Google Scholar 

  11. Hayakawa K, Ishikawa M, Yamaki K (2004) Ultrastructural changes in rat eyes with experimental Vogt–Koyanagi–Harada disease. Jpn J Ophthalmol 48:222–227

    Article  PubMed  Google Scholar 

  12. Yamaki K, Takiyama N, Itho N, Mizuki N, Seiya M, Sinsuke W, Hayakawa K, Kotani T (2005) Experimentally induced Vogt–Koyanagi–Harada disease in two Akita dogs. Exp Eye Res 80:273–280

    Article  PubMed  CAS  Google Scholar 

  13. Aoyagi R, Hayashi T, Masai A, Mitooka K, Gekka T, Kozaki K, Tsuneoka H (2012) Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom 95:212–217

    Article  PubMed  Google Scholar 

  14. Shiono A, Kogo J, Klose G, Takeda H, Ueno H, Tokuda N, Inoue J, Matsuzawa A, Kayama N, Ueno S, Takagi H (2013) Photoreceptor outer segment length: a prognostic factor for idiopathic epiretinal membrane surgery. Ophthalmology 120:788–794

    Article  PubMed  Google Scholar 

  15. Matsumoto H, Kishi S, Otani T, Sato T (2008) Elongation of photoreceptor outer segment in central serous chorioretinopathy. Am J Ophthalmol 145:162–168

    Article  PubMed  Google Scholar 

  16. Boretsky A, Mirza S, Khan F, Motamedi M, van Kuijk FJ (2013) High-resolution multimodal imaging of multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 44:296–300

    Article  PubMed  Google Scholar 

  17. Heussen FM, Ouyang Y, McDonnell EC, Narala R, Ruiz-Garcia H, Walsh AC, Sadda SR (2012) Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments. Br J Ophthalmol 96:380–385

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Funding/support

Support of this study was provided by Researches on Sensory and Communicative Disorders from the Ministry of Health, Labor, and Welfare, Japan.

Disclosure statement

No author has a financial or proprietary interest in any material or method mentioned.

Conflict of interest

None

Data access and responsibility

The corresponding author (KShinoda) has full access to all of the data in the study, and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Contributions of authors

Conception and design of study (R.A., I.K., K.Shinoda); conduct of study (R.A., I.K.,Y.I., K.Shinoda); collection of data (K.Shinoda.,Y.I., K.Seki., M.I., A.Mizota); analysis and interpretation of data (R.A., I.K.,Y.I., K.Shinoda); preparation of the manuscript (Y.I., K.Shinoda); critical revision (Y.I., CS.M.); obtain funding (K.Shinoda, A.Mizota.); literature search (K.Shinoda, Y.I.); administrative support (M.I., A.Murakami, A.Mizota.); and review and approval of the manuscript (R.A., I.K.,Y.I., K.Shinoda., CS.M., K.Seki. M.I.,A.Murakami., A.Mizota.)

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Juntendo University Urayasu Hospital, Chiba, Japan

    Rei Arai & Itaru Kimura

  2. Laboratory of Neurobiology, Division of Molecular & Cellular Biology, National Hospital Organization, Tokyo Medical Center, National Institute of Sensory Organs, Tokyo, Japan

    Itaru Kimura

  3. Department of Ophthalmology, Teikyo University School of Medicine, University Hospital Mizonokuchi, Kanagawa, Japan

    Yutaka Imamura & Masahiro Ishida

  4. Department of Ophthalmology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-0003, Japan

    Kei Shinoda, Celso Soiti Matsumoto, Keisuke Seki & Atsushi Mizota

  5. Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan

    Akira Murakami

Authors
  1. Rei Arai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Itaru Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yutaka Imamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kei Shinoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Celso Soiti Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Keisuke Seki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masahiro Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Akira Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Atsushi Mizota
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kei Shinoda.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arai, R., Kimura, I., Imamura, Y. et al. Photoreceptor inner and outer segment layer thickness in multiple evanescent white dot syndrome. Graefes Arch Clin Exp Ophthalmol 252, 1645–1651 (2014). https://doi.org/10.1007/s00417-014-2747-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-014-2747-7

Keywords

Search

Navigation