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Visual outcome and prognostic factors after surgery for a secondary epiretinal membrane associated with branch retinal vein occlusion

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To assess the visual outcome and prognostic factors after surgery for a secondary epiretinal membrane (ERM) due to branch retinal vein occlusion (BRVO).

Methods

Medical records of 33 patients (33 eyes) were retrospectively reviewed. All patients underwent vitrectomy and completed at least one year of follow-up. Patients characteristics, including baseline best-corrected visual acuity (BCVA; logMAR, logarithm of the minimum angle resolution), fluorescein angiography and optical coherence tomography findings were analyzed.

Results

Twenty eyes (60.6%) were non-ischemic and nine eyes (27.3%) had ischemic maculopathy. The mean BCVA was 0.82 ±0.56 logMAR (20/132 Snellen equivalent) at baseline and 0.43 ±0.37 logMAR (20/53 Snellen equivalent) at 1 year (p = 0.001). At 1 year three eyes (9.1%) had visual loss with 0.3 logMAR or more deterioration than baseline whereas 16 eyes (48.5%) gained vision. The mean central macular thickness (CMT) was 407.3 ±138.8 μm at baseline and 274.71 ±40.5 μm at 1 year after surgery (p = 0.001). Photoreceptor integrity was intact in 20 eyes (60.6%). Photoreceptor integrity (B = 0.248, p = 0.001) at baseline was significantly correlated with visual outcome after surgery.

Conclusion

Surgery for a secondary ERM associated with BRVO led to a relatively favorable visual outcome. The integrity of photoreceptors at baseline seems to be useful in predicting visual outcome in these patients.

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References

  1. Klein R, Klein BE, Moss SE, Meuer SM (2000) The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc 98:133–141

    PubMed Central  CAS  PubMed  Google Scholar 

  2. Rehak J, Rehak M (2008) Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res 33:111–131

    Article  PubMed Central  PubMed  Google Scholar 

  3. Jaulim A, Ahmed B, Khanam T, Chatziralli IP (2013) Branch retinal vein occlusion. Epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina 33:901–910

    Article  PubMed  Google Scholar 

  4. Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 114:1243–1247

    Article  CAS  PubMed  Google Scholar 

  5. Wong TY, Scott IU (2010) Clinical practice. Retinal vein occlusion. N Eng J Med 363:2135–2144

    Article  CAS  Google Scholar 

  6. Lang GE, Freissler K (1992) Clinical and fluorescein angiography findings in patients with retinal vein occlusion. A unicenter study of 211 patients. Klin Monbl Augenheilkd 201:234–239

    Article  CAS  PubMed  Google Scholar 

  7. Shilling JS, Kohner EM (1976) New vessel formation in retinal branch vein occlusion. Br J Ophthalmol 60:810–815

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Singh M, Dhir L, Kon C, Rassam S (2006) Tractional retinal break and rhegmatogenous retinal detachment consequent to branch retinal vein occlusion. Eye 20:1326–1327

    Article  CAS  PubMed  Google Scholar 

  9. Apostolopoulos M, Koutsandrea C, Chatjoulis D, Ladas J, Theodossiadis G (1995–1996) Late complications in branch retinal vein occlusion. Int Ophthalmol 19:281–285

  10. Takahashi M, Hirokawa H, Trempe CL (1981) Vitreous detachment, neovascularization, and vitreous hemorrhage in retinal branch vein occlusion. Nihon Ganka Gakkai Zasshi 85:731–736

    CAS  PubMed  Google Scholar 

  11. Mitchell P, Smith W, Chey T, Wang JJ, Chang A (1997) Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia. Ophthalmology 10:1033–1040

    Article  Google Scholar 

  12. Amirikia A, Scott IU, Murray TG, Flynn HW Jr, Smiddy WE, Feuer WJ (2001) Outcomes of vitreoretinal surgery for complications of branch retinal vein occlusion. Ophthalmology 108:372–376

    Article  CAS  PubMed  Google Scholar 

  13. Hvarfner C, Andreasson S, Larsson J (2006) Multifocal electroretinography and fluorescein angiography in retinal vein occlusion. Retina 26:292–296

    Article  PubMed  Google Scholar 

  14. Puliafito CA, Hee MR, Lin CP, Reichel E, Schuman JS, Duker JS, Izatt JA, Swanson EA, Fujimoto JG (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102:217–229

    Article  CAS  PubMed  Google Scholar 

  15. Kang HM, Chung EJ, Kim YM, Koh HJ (2013) Spectral-domain optical coherence tomography (SD-OCT) patterns and response to intravitreal bevacizumab therapy in macular edema associated with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 251:501–508

    Article  CAS  PubMed  Google Scholar 

  16. Suh MH, Seo JM, Park KH, Yu HG (2009) Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal. Am J Ophthalmol 147:473–480

    Article  PubMed  Google Scholar 

  17. Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S, Arakawa A, Kadonosono K (2010) Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane. Am J Ophthalmol 150:834–839

    Article  PubMed  Google Scholar 

  18. Mitamura Y, Hirano K, Baba T, Yamamoto S (2009) Correlation of visual recovery with presence of photoreceptor inner/outer segment junction in optical coherence images after epiretinal surgery. Br J Ophthalmol 93:171–175

    Article  CAS  PubMed  Google Scholar 

  19. Kim JH, Kim YM, Chung EJ, Lee SY, Koh HJ (2012) Structural and functional predictors of visual outcome of epiretinal membrane surgery. Am J Ophthalmol 153:103–110

    Article  PubMed  Google Scholar 

  20. Branch Vein Occlusion Study Group (1986) Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch retinal vein occlusion. A randomized clinical trial. Arch Ophthalmol 104:34–41

    Article  Google Scholar 

  21. Oster SF, Mojana F, Brar M, Yuson RM, Cheng L, Freeman WR (2010) Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina 30:713–718

    Article  PubMed  Google Scholar 

  22. Falkner-Radler CI, Glittenberg C, Hagen S, Benesch T, Binder S (2010) Spectral-domain optical coherence tomography for monitoring epiretinal membrane surgery. Ophthalmology 117:798–805

    Article  PubMed  Google Scholar 

  23. Hiscott PS, Grierson I, McLeod D (1985) Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol 69:810–823

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Bochaton-Piallat ML, Kapetanios AD, Donati G, Redard M, Gabbiani G, Pournaras CJ (2000) TGF-beta 1, TGF-beta receptor II and ED-A fibronectin expression in myofibroblast of vitreoretinopathy. Invest Ophthalmol Vis Sci 41:2336–2342

    CAS  PubMed  Google Scholar 

  25. Harada C, Mitamura Y, Harada T (2006) The role of cytokines and trophic factors in epiretinal membranes: involvement of signal transduction in glial cells. Prog Retin Eye Res 25:149–164

    Article  CAS  PubMed  Google Scholar 

  26. Mori K, Gehlbach PL, Sano A, Deguchi T, Yoneya S (2004) Comparison of epiretinal membranes of differing pathogenesis using optical coherence tomography. Retina 24:57–62

    Article  PubMed  Google Scholar 

  27. Sakimoto S, Saito Y, Nakata K, Sakamoto Y, Tatebayashi M (2008) Surgical outcomes of epiretinal membrane removal after successful pars plana vitrectomy for retinal diseases. Jpn J Ophthalmol 52:227–230

    Article  PubMed  Google Scholar 

  28. Benichou C, Flament J (1989) (1989) Epiretinal membrane and photocoagulation with argon laser. Discussion of 3 cases. Bull Soc Ophtalmol Fr 89:613–619

    CAS  PubMed  Google Scholar 

  29. Marticorena J, Romano MR, Heimann H, Stappler T, Gibran K, Groenewald C, Pearce I, Wong D (2011) Intravitreal bevacizumab for retinal vein occlusion and early growth of epiretinal membrane: a possible secondary effect? Br J Ophthalmol 95:391–395

    Article  PubMed  Google Scholar 

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Acknowledgments

Funding/support

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Financial disclosure

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Contributions of authors

Design and conduct of study (HM Kang); collection of data (HM Kang); management, analysis, and interpretation of data (HM Kang, HJ Koh, SC Lee); and preparation, review, and approval of the manuscript (HM Kang, HJ Koh, SC Lee).

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Author information

Authors and Affiliations

  1. Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea

    Hae Min Kang & Hyoung Jun Koh

  2. Department of Ophthalmology, International St. Mary’s Hospital, Incheon, Republic of Korea

    Hae Min Kang

  3. Department of Ophthalmology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-gu, Seoul, 120-752, Republic of Korea

    Sung Chul Lee

Authors
  1. Hae Min Kang
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  2. Hyoung Jun Koh
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  3. Sung Chul Lee
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Correspondence to Sung Chul Lee.

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Kang, H.M., Koh, H.J. & Lee, S.C. Visual outcome and prognostic factors after surgery for a secondary epiretinal membrane associated with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 253, 543–550 (2015). https://doi.org/10.1007/s00417-014-2731-2

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  • DOI: https://doi.org/10.1007/s00417-014-2731-2

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