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Elevated intraocular pressure in patients with acromegaly

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate central corneal thickness (CCT) and intraocular pressure (IOP) in a cohort of acromegalic patients, and to correlate CCT with serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).

Methods

Consecutive patients affected by acromegaly underwent a comprehensive endocrinological and ophthalmological evaluation, including serum GH and IGF-1 levels, CCT measured with ultrasonic pachymetry and IOP assessed with Goldmann applanation tonometry.

Results

Fourteen patients with acromegaly and 28 healthy controls were included in the study. Acromegalic patients had a statistically higher median CCT (570 μm [range 551.5–638] vs 542.7 μm [range 461.5–610]; p < 0.01) and higher median IOP (17.2 mm Hg [range 14–21] vs 13.7 mm Hg [range 10.5–19]; p < 0.01) than healthy controls. No statistically significant correlation was found among CCT and GH, CCT and IGF-1, IOP and GH, IOP and IGF-1 in the acromegalic group, whereas a statistically significant correlation was documented between CCT and IOP in the entire cohort (Spearman’s correlation coefficient: 0.56, p < 0.01). However, when IOP was corrected for CCT no significant difference was found between the two study groups (p = 0.07).

Conclusions

Our results suggest that acromegaly is associated with an increased CCT, which could lead to an overestimation of IOP readings as determined with Goldmann applanation tonometry.

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Authors and Affiliations

  1. Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy

    Luciano Quaranta & Ivano Riva

  2. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Gherardo Mazziotti, Teresa Porcelli & Andrea Giustina

  3. IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

    Irene Floriani

  4. Ophthalmology Department, University of Ioannina, Ioannina, Greece

    Andreas Katsanos

  5. Glaucoma Unit, Department of Ophthalmology, 1st University, AHEPA Hospital, Thessaloniki, Greece

    Anastasios G. P. Konstas

  6. USVD “Centro per lo Studio del Glaucoma”, Piazzale Spedali Civili 1, 25123, Brescia, Italy

    Luciano Quaranta

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  1. Luciano Quaranta
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  2. Ivano Riva
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  3. Gherardo Mazziotti
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  4. Teresa Porcelli
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  5. Irene Floriani
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Correspondence to Luciano Quaranta.

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Quaranta, L., Riva, I., Mazziotti, G. et al. Elevated intraocular pressure in patients with acromegaly. Graefes Arch Clin Exp Ophthalmol 252, 1133–1139 (2014). https://doi.org/10.1007/s00417-014-2650-2

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  • DOI: https://doi.org/10.1007/s00417-014-2650-2

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