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The effect of intracameral anesthesia on macular thickness and ganglion cell-inner plexiform layer thickness after uneventful phacoemulsification surgery: prospective and randomized controlled trial

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Abstract

Background

To evaluate the effect of intracameral lidocaine anesthesia on macular thickness and macular ganglion cell-inner plexiform layer (GC-IPL) thickness following uneventful phacoemusification in healthy subjects.

Methods

This is a prospective, randomized and double- masked study. One hundred eyes of 74 consecutive patients were randomized to receive intracameral preservative-free lidocaine 1 % (intracameral lidocaine group) or intracameral injection of balanced salt solution (sham injection group) at the time of the phacoemulsification surgery. Preoperative and postoperative macular thickness analyses with spectral domain optical coherence tomography (SD-ODT) were performed and the results between the two groups were compared.

Results

Postoperatively, both the central foveal thickness (CFT) and the thickness of perifoveal macula were significantly improved in both groups (p < 0.001). There was no statistically significant difference between CFT and the inner and outer macular zone thicknesses of the two groups at any follow-up time. In both groups, GC-IPL thickness was significantly increased at the first week and first month visits (p < 0.001). There was no statistically significant difference between GC-IPL thickness measurements of the two groups at any follow-up time.

Conclusion

The current study demonstrated that supplementary intracameral lidocaine 1 % did not cause more macular thickening than the intracameral sham injection during a follow-up period of 3 months. The present study also showed a tendency for a transient increase in high definition SD-OCT–based GC-IPL thickness measurements within a few months following cataract surgery under both intracameral lidocaine anesthesia and intracameral sham injection.

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Acknowledgments

None of the authors indicate governmental or non-governmental financial support. The authors indicate no financial or proprietary interest in any material or method mentioned.

We would like to thank Prof Said Bodur for the statistical analyses.

None of the authors has a financial interest in any material and method mentioned herein.

This study was registered at http://www.controlled-trials.com with a number of ISRCTN94155463.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Ophthalmology, Balikesir University, Balikesir, Turkey

    Esin Sogutlu Sari, Sitki Samet Ermis, Alper Yazici, Gözde Sahin & Adil Kilic

  2. Faculty of Medicine, Department of Ophthalmology, Bezmialem Vakif University, Istanbul, Turkey

    Arif Koytak

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  1. Esin Sogutlu Sari
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  2. Sitki Samet Ermis
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  3. Alper Yazici
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Correspondence to Esin Sogutlu Sari.

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Sari, E.S., Ermis, S.S., Yazici, A. et al. The effect of intracameral anesthesia on macular thickness and ganglion cell-inner plexiform layer thickness after uneventful phacoemulsification surgery: prospective and randomized controlled trial. Graefes Arch Clin Exp Ophthalmol 252, 433–439 (2014). https://doi.org/10.1007/s00417-013-2557-3

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  • DOI: https://doi.org/10.1007/s00417-013-2557-3

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