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Combination of optic disc rim area and retinal nerve fiber layer thickness for early glaucoma detection by using spectral domain OCT

  • Glaucoma
  • Published:
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Abstract

Background

To compare the diagnostic ability of optic disc rim area (RA), retinal nerve fiber layer thickness (RNFLT), and their combination on sector-based analysis of spectral domain optical coherence tomography (Cirrus OCT) in discriminating subjects with early-stage open angle glaucoma (OAG) from normal subjects.

Methods

RA and RNFLT of 78 early OAG and 80 normal subjects were measured on Cirrus OCT at the global area, 4 quadrants, 12 clock hours, and 7 + 11 o’clock (a sector that includes 7 and 11 o’clock). A new parameter, RR (a multiplication of the RA and RNFLT) was derived to identify the best combination of the two parameters. Areas under the receiver operating characteristics curves (AUCs) of RA, RNFLT, and RR were compared.

Results

AUCs of RA were larger than those of RNFLT at nasal quadrant, at 1–5 o’clock on Cirrus OCT (all P values < 0.05). At the remaining areas, the two parameters were not significantly different on both devices (all P values > 0.05). RR had significantly larger AUCs than those of both RA and RNFLT at 7 + 11 o’clock (0.931 for RA, 0.933 for RNFLT, and 0.968 for RR) and global area (0.914 for RA, 0.905 for RNFLT, and 0.935 for RR), which were the two areas with largest AUCs.

Conclusions

RR outperformed both RA and RNFLT of the Cirrus OCT, especially at areas with diagnostic importance. This suggests that combinations of RA and RNFLT by sector-based analysis of Cirrus OCT would be promising to determine early glaucoma.

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Conflict of interest

No authors have any financial/conflicting interests to disclose.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Haeundae Paik Hospital, 1435 Jwa-dong, Haeundae-gu, Busan, 612-030, Korea

    Min Hee Suh

  2. Department of Ophthalmology, Inje University College of Medicine, Busan, Korea

    Min Hee Suh

  3. Samsung Advanced Institute of Technology, Yongin, Korea

    Sun Kwon Kim

  4. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

    Ki Ho Park, Dong Myung Kim & Seok Hwan Kim

  5. Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea

    Ki Ho Park & Dong Myung Kim

  6. Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, Korea

    Seok Hwan Kim

  7. Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea

    Hee Chan Kim

Authors
  1. Min Hee Suh
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  2. Sun Kwon Kim
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  3. Ki Ho Park
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  4. Dong Myung Kim
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Corresponding author

Correspondence to Min Hee Suh.

Additional information

This work was supported by a 2012 Inje University research grant.

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Suh, M.H., Kim, S.K., Park, K.H. et al. Combination of optic disc rim area and retinal nerve fiber layer thickness for early glaucoma detection by using spectral domain OCT. Graefes Arch Clin Exp Ophthalmol 251, 2617–2625 (2013). https://doi.org/10.1007/s00417-013-2468-3

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  • DOI: https://doi.org/10.1007/s00417-013-2468-3

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