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Tocilizumab treatment for refractory uveitis-related cystoid macular edema

  • Alfredo AdánEmail author
  • Marina Mesquida
  • Victor Llorenç
  • Gerard Espinosa
  • Blanca Molins
  • Maria V. Hernández
  • Laura Pelegrín
Inflammatory Disorders

Abstract

Background

This retrospective study investigated the efficacy of tocilizumab (TCZ), a fully humanized antibody that binds both to soluble and membrane bound IL-6 receptors, for the treatment of uveitis-related cystoid macular edema (CME) refractory to immunomodulatory therapy.

Methods

Five refractory patients with uveitis-related CME who received TCZ between January and August 2012 were included. All patients received 8 mg/kg TCZ at 4-week intervals. Data regarding patient demographics, use of immunosuppressive drugs, biologic agents or intravitreal therapies prior to TCZ infusions were collected. Main outcome measure was central foveal thickness (CFT) measured by optical coherence tomography at 6 months. Secondary outcome measures were degree of anterior and posterior chamber inflammation (Standardization of Uveitis Nomenclature Working Group criteria) and visual acuity (logarithm of the minimum angle of resolution [log-MAR]) at month 6. Adverse events (AEs) related to TCZ therapy were also assessed.

Results

Eight eyes from five patients (all females) were included. Mean age was 49.4 years (range, 30–68). Mean follow-up was 8.4 months (range, 6–12). Before TCZ, all patients received and failed conventional immunosuppressive therapy and had received at least another biologic agent. Uveitis diagnoses were Birdshot chorioretinopathy (n = 3), juvenile idiopathic arthritis (JIA)-associated uveitis (n = 1), and idiopathic panuveitis (n = 1). Mean evolution of CME was 13.4 years (range, 2–30). Mean baseline CFT (95 % confidence interval) was 602 ± 236 μm at baseline, 386 ± 113 μm at month 1 (p = 0.006), 323 ± 103 μm at month 3 (p = 0.026), and 294.5 ± 94.5 μm at month 6 (p = 0.014). Median best-corrected visual acuity (BCVA) improved from 0.66 ± 0.57 at baseline to 0.47 ± 0.62 at month 6 (p = 0.035). After 6 months, an improvement of ≥ 2 lines of BCVA was observed in 50 % of eyes (p = 0.028) remained stable in 25 % and worsened in none of the patients. Sustained uveitis remission was achieved in all patients. No AEs were reported.

Conclusions

These data suggest that TCZ is effective for treating CME in otherwise treatment-refractory cases of uveitis.

Keywords

Tocilizumab Uveitis Macular edema 

Notes

Financial support

None.

Conflict of interest

No conflicting relationship exists for any author.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Alfredo Adán
    • 1
    Email author
  • Marina Mesquida
    • 1
  • Victor Llorenç
    • 1
  • Gerard Espinosa
    • 3
  • Blanca Molins
    • 4
  • Maria V. Hernández
    • 2
  • Laura Pelegrín
    • 1
  1. 1.Department of Ophthalmology, Hospital Clínic of BarcelonaUniversitat of BarcelonaBarcelonaSpain
  2. 2.Department Rheumatology, Hospital Clinic of BarcelonaUniversitat of BarcelonaBarcelonaSpain
  3. 3.Department of Autoimmune Diseases, Hospital Clinic of BarcelonaUniversitat of BarcelonaBarcelonaSpain
  4. 4.Fundació Clínic per la Recerca Biomèdica, IDIBAPSBarcelonaSpain

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