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Peripheral optical quality and myopia progression in children

  • Pediatrics
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To investigate the peripheral optical quality and its relationship with axial elongation, myopic progression in Japanese children.

Methods

Twenty-nine Japanese children, ages 10 to 12 years old, with baseline refraction from +0.75D to −5.5 D, were included and followed for 9 months. The central and peripheral point spread functions (PSFs; 0°, 10°, 20°, 30° nasally) were obtained at 0.25 D steps around ±2.5 D of best-focus PSF (BF-PSF) using double-pass PSF system. Modulation transfer function (MTF) area of the BF-PSF was calculated from BF-PSF to represent the peripheral optical quality. Relative peripheral defocus (RPD), the refraction of anterior/posterior focal lines, MTF area, and their correlations with myopia progression were analyzed.

Results

The average refractive change in 9 months was −0.5 ± 0.8 D. The change in axial length was significantly positively correlated with the amount of myopic progression (P = 0.0058) and RPD (P = 0.0007, 0.0036 and 0.0040, at 10°, 20°, 30° respectively) at the initial visit, but did not correlate with the peripheral MTF area. Myopic progression of more than 0.5 D with axial elongation was observed in seven children (MP group). The RPDs at 20° and 30° in the MP group were significantly more hyperopic than in the non-MP group (P = 0.002 and 0.007), whereas there was no significant difference in axial length, and central and peripheral MTF area between the MP and non-MP groups. MP group had more hyperopic focal lines compared with non-MP group at 20°and 30°.

Conclusion

These results suggest that the progression of axial myopia in children is associated with hyperopic RPD and refraction of focal lines, not with peripheral optical quality.

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Acknowledgments

This study was supported by a grant from the Japan Society for the Promotion of Science (No. 22791697). We thank Toru Noda for the advice and supports. We thank Deshea Harris for editing and correcting English of the manuscript. We thank Chiyo Kodama and Maki Akita for technical assistance.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa, Chiba, Japan, 272-8513

    Takefumi Yamaguchi, Kenji Konomi, Yoshiyuki Satake & Jun Shimazaki

  2. Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

    Takefumi Yamaguchi, Jun Shimazaki & Kazuno Negishi

  3. Department of Medical System Engineering, Faculty of Engineering, Chiba University, Chiba, Japan

    Kazuhiko Ohnuma

Authors
  1. Takefumi Yamaguchi
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  2. Kazuhiko Ohnuma
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  3. Kenji Konomi
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  4. Yoshiyuki Satake
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  5. Jun Shimazaki
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Correspondence to Takefumi Yamaguchi.

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The sponsor or funding organization had no role in the design or conduct of this research. No conflicting relationship exists for any author.

Financial support

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research 20791274 (TY).

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Yamaguchi, T., Ohnuma, K., Konomi, K. et al. Peripheral optical quality and myopia progression in children. Graefes Arch Clin Exp Ophthalmol 251, 2451–2461 (2013). https://doi.org/10.1007/s00417-013-2398-0

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  • DOI: https://doi.org/10.1007/s00417-013-2398-0

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