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Long-term anatomical and functional outcomes of idiopathic macular hole surgery. The yield of spectral-domain OCT combined with microperimetry

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To evaluate the correlations between anatomical and functional changes studied with microperimetry (MPM) and spectral-domain OCT (SD-OCT) in patients after successful repair of idiopathic macular hole (MH).

Methods

Monocentric, retrospective, interventional study in 23 eyes of 23 patients who underwent successful surgery for MH defined as closure of the hole, at least 1 year before. Reported data were pre- and postoperative best-corrected visual acuity (BCVA), retinal sensitivity values on MPM, macular and foveal thicknesses, and retinal anatomic lesions on SD-OCT.

Results

Macular sensitivity (MS) and foveal sensitivity (FS) were lower and the number of lesions of the outer retinal layers was higher in patients with a poorer postoperative VA (P = 0.029, P = 0.011 and P = 0.003 respectively). Preoperative MH size was lower and MS and FS were better in patients with a preserved junction line between the inner and outer segments of photoreceptors (IS/OS) (P = 0.045, P = 0.001, and P = 0.001 respectively). Better postoperative VA was correlated with better preoperative VA (P = 0.012, r = 0.513). Postoperative VA was correlated with MS and FS (P = 0.032, r = 0.449, and P = 0.019, r = 0.483 respectively). Greater foveal thickness was associated with better postoperative VA (P = 0.020, r = 0.482).

Conclusion

Postoperative outer retinal layer integrity is associated with better final retinal sensitivity. Further studies are warranted to assess the role of SD-OCT and microperimetry in the pre- and postoperative evaluation of idiopathic macular holes.

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References

  1. Kelly NE, Wendel RT (1991) Vitreous surgery for idiopathic macular holes. Results of a pilot study. Arch Ophthalmol 109:654–659

    Article  PubMed  CAS  Google Scholar 

  2. Brooks HL Jr (2000) Macular hole surgery with and without internal limiting membrane peeling. Ophthalmology 107:1939–1948, discussion 1948-1939

    Article  PubMed  Google Scholar 

  3. Kumagai K, Furukawa M, Ogino N, Uemura A, Demizu S, Larson E (2004) Vitreous surgery with and without internal limiting membrane peeling for macular hole repair. Retina 24:721–727

    Article  PubMed  Google Scholar 

  4. Christensen UC (2009) Value of internal limiting membrane peeling in surgery for idiopathic macular hole and the correlation between function and retinal morphology. Acta Ophthalmol 2:1–23, 87 Thesis

    Article  Google Scholar 

  5. Baba T, Yamamoto S, Arai M, Arai E, Sugawara T, Mitamura Y, Mizunoya S (2008) Correlation of visual recovery and presence of photoreceptor inner/outer segment junction in optical coherence images after successful macular hole repair. Retina 28:453–458

    Article  PubMed  Google Scholar 

  6. Chen WC, Wang Y, Li XX (2012) Morphologic and functional evaluation before and after successful macular hole surgery using spectral-domain optical coherence tomography combined with microperimetry. Retina 32:1733–1742

    PubMed  CAS  Google Scholar 

  7. Chung H, Shin CJ, Kim JG, Yoon YH, Kim HC (2011) Correlation of microperimetry with fundus autofluorescence and spectral-domain optical coherence tomography in repaired macular holes. Am J Ophthalmol 151:128–136

    Article  PubMed  Google Scholar 

  8. Inoue M, Arakawa A, Yamane S, Watanabe Y, Kadonosono K (2012) Long-term outcome of macular microstructure assessed by optical coherence tomography in eyes with spontaneous resolution of macular hole. Am J Ophthalmol 153:687–691

    Article  PubMed  Google Scholar 

  9. Itoh Y, Inoue M, Rii T, Hiraoka T, Hirakata A (2012) Correlation between length of foveal cone outer segment tips line defect and visual acuity after macular hole closure. Ophthalmology 119:1438–1446

    Article  PubMed  Google Scholar 

  10. Kim NM, Park HJ, Koo GH, Lee JE, Oum BS (2011) Photoreceptor layer assessed in tissue layer image using spectral-domain optical coherence tomography after surgical closure of macular hole. Retina 31:1483–1492

    Article  PubMed  Google Scholar 

  11. Ooka E, Mitamura Y, Baba T, Kitahashi M, Oshitari T, Yamamoto S (2011) Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery. Am J Ophthalmol 152:283–290

    Article  PubMed  Google Scholar 

  12. Sano M, Shimoda Y, Hashimoto H, Kishi S (2009) Restored photoreceptor outer segment and visual recovery after macular hole closure. Am J Ophthalmol 147:313–318

    Article  PubMed  Google Scholar 

  13. Shimozono M, Oishi A, Hata M, Kurimoto Y (2011) Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure: spectral-domain optical coherence tomography analysis. Graefes Arch Clin Exp Ophthalmol 249:1469–1476

    Article  PubMed  Google Scholar 

  14. Sun Z, Gan D, Jiang C, Wang M, Sprecher A, Jiang AC, Xu G (2012) Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes. Graefes Arch Clin Exp Ophthalmol 250:1587–1596

    Article  PubMed  Google Scholar 

  15. Wakabayashi T, Fujiwara M, Sakaguchi H, Kusaka S, Oshima Y (2010) Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis. Ophthalmology 117:1815–1824

    Article  PubMed  Google Scholar 

  16. Landa G, Rosen RB, Garcia PM, Seiple WH (2010) Combined three-dimensional spectral OCT/SLO topography and microperimetry: steps toward achieving functional spectral OCT/SLO. Ophthalmic Res 43:92–98

    Article  PubMed  Google Scholar 

  17. Richter-Mueksch S, Vecsei-Marlovits PV, Sacu SG, Kiss CG, Weingessel B, Schmidt-Erfurth U (2007) Functional macular mapping in patients with vitreomacular pathologic features before and after surgery. Am J Ophthalmol 144:23–31

    Article  PubMed  Google Scholar 

  18. Gass JD (1995) Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol 119:752–759

    PubMed  CAS  Google Scholar 

  19. Kumagai K, Ogino N, Furukawa M, Hangai M, Kazama S, Nishigaki S, Larson E (2012) Retinal thickness after vitrectomy and internal limiting membrane peeling for macular hole and epiretinal membrane. Clin Ophthalmol 6:679–688

    Article  PubMed  Google Scholar 

  20. Meng Q, Zhang S, Ling Y, Cui D, Jin Y (2011) Long-term anatomic and visual outcomes of initially closed macular holes. Am J Ophthalmol 151:896–900

    Article  PubMed  Google Scholar 

  21. Oh IK, Oh J, Yang SM, Ahn SE, Kim SW, Huh K (2012) Hyperreflective external limiting membranes after successful macular hole surgery. Retina 32:760–766

    Article  PubMed  Google Scholar 

  22. Oh J, Yang SM, Choi YM, Kim SW, Huh K (2013) Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 251(2):477–484. doi:10.1007/s00417-012-2058-9

    Article  PubMed  Google Scholar 

  23. Ooto S, Hangai M, Takayama K, Ueda-Arakawa N, Hanebuchi M, Yoshimura N (2012) Photoreceptor damage and foveal sensitivity in surgically closed macular holes: an adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol 154:174–186

    Article  PubMed  Google Scholar 

  24. Cappello E, Virgili G, Tollot L, Del Borrello M, Menchini U, Zemella M (2009) Reading ability and retinal sensitivity after surgery for macular hole and macular pucker. Retina 29:1111–1118

    Article  PubMed  Google Scholar 

  25. Delolme MP, Dugas B, Nicot F, Muselier A, Bron AM, Creuzot-Garcher C (2012) Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off. Am J Ophthalmol 153:128–136

    Article  PubMed  Google Scholar 

  26. Ruiz-Moreno JM, Lugo F, Montero JA, Pinero DP (2012) Restoration of macular structure as the determining factor for macular hole surgery outcome. Graefes Arch Clin Exp Ophthalmol 250:1409–1414

    Article  PubMed  Google Scholar 

  27. Bottoni F, De Angelis S, Luccarelli S, Cigada M, Staurenghi G (2011) The dynamic healing process of idiopathic macular holes after surgical repair: a spectral domain optical coherence tomography study. Invest Ophthalmol Vis Sci 52:4439–4446

    Article  PubMed  Google Scholar 

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Financial interest

The authors do not have any financial interest in any device or drug mentioned in this study.

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Authors and Affiliations

  1. Department of Ophthalmology University Hospital, Dijon, France

    Arnaud Bonnabel, Alain M. Bron, Rodica Isaico, Brice Dugas, Frédéric Nicot & Catherine Creuzot-Garcher

  2. Service d’ophtalmologie, CHU Dijon, 3, Rue du Faubourg Raines, 21000, Dijon, France

    Catherine Creuzot-Garcher

Authors
  1. Arnaud Bonnabel
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  2. Alain M. Bron
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  3. Rodica Isaico
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  4. Brice Dugas
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  5. Frédéric Nicot
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  6. Catherine Creuzot-Garcher
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Corresponding author

Correspondence to Catherine Creuzot-Garcher.

Additional information

The authors have full control of all primary data, and they agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review their data upon request.

The registration number of our study is NCT01757600.

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Bonnabel, A., Bron, A.M., Isaico, R. et al. Long-term anatomical and functional outcomes of idiopathic macular hole surgery. The yield of spectral-domain OCT combined with microperimetry. Graefes Arch Clin Exp Ophthalmol 251, 2505–2511 (2013). https://doi.org/10.1007/s00417-013-2339-y

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  • DOI: https://doi.org/10.1007/s00417-013-2339-y

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