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Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy

  • Neurophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

P-selectin receptor is expressed in platelets and endothelial cells in a cell-activation-dependent manner. Platelet P-selectin (CD62) levels may become elevated in a number of vasoocclusive diseases, including arteriosclerosis, atherothrombosis, and diabetes mellitus (DM). Nonarteritic anterior ischemic optic neuropathy (NAION) is associated with a sudden loss of vision due to the vascular insufficiency of ciliary arteries supplying the optic nerve. In this study, our aim was to investigate the presence of increased platelet reactivity in the development of NAION.

Methods

Twenty-one NAION patients, 39 healthy control subjects, and 44 patients suffering from diabetes mellitus (DM) were examined in our case-control, pilot study. Platelet activation was investigated by flow cytometric analysis of the mean fluorescence intensity (MFI) of CD62 on platelets. These results were compared among the different study groups.

Results

NAION patients showed considerably although not signifactly (p = 0.2017) higher P-selectin MFI values (71.98 ± 40.30) versus healthy subjects (55.48 ± 20.95), insulin-dependent DM patients (50.02 ± 13.08), and non-insulin-dependent DM subjects (54.72 ± 24.74). However, logistic regression analysis resulted in a statistically significant adjusted effect on the odds of NAION when CD62 MFI values were logarithmically transformed (OR: 3.86, 95 % CI: 1.10 to 13.53, p = 0.0346).

Conclusion

Elevated platelet CD62 positivity may be related to NAION, suggesting a possible role of enlarged platelet activity in the generation of this type of ischemic optic neuropathy.

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Authors and Affiliations

  1. Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary

    Valeria Nagy, Bence Kolozsvari, Zsuzsa Balogh, Adrienne Csutak & Andras Berta

  2. Department of Ophthalmology, Hungarian Military Hospital, Budapest, Hungary

    Marta Kasza

  3. Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary

    Bela Nagy Jr

  4. Kenezy Hospital — Institute of Infectology, Debrecen, Hungary

    Laszlo Kardos

  5. Division of Rare Diseases, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012, Debrecen, Hungary

    Gyorgy Pfliegler

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  1. Valeria Nagy
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  2. Bence Kolozsvari
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Corresponding author

Correspondence to Valeria Nagy.

Additional information

Valeria Nagy and Bence Kolozsvari equally contributed to this paper as first authors.

The authors have no conflict of interest in this study. This paper has not been published or submitted for publication elsewhere.

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Nagy, V., Kolozsvari, B., Balogh, Z. et al. Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 251, 917–922 (2013). https://doi.org/10.1007/s00417-012-2196-0

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  • DOI: https://doi.org/10.1007/s00417-012-2196-0

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