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Increased lens vault as a risk factor for angle closure: confirmation in a Japanese population

Graefe's Archive for Clinical and Experimental Ophthalmology volume 250, pages 1863–1868 (2012)Cite this article

Abstract

Purpose

A thicker lens vault (LV), measured by anterior segment optical coherence tomography (ASOCT), was recently identified as a novel risk factor for angle closure in Chinese Singaporeans. The purpose of our study was to investigate the association of LV with angle closure in Japanese subjects.

Design

Case–control study

Methods

One hundred and twenty-four subjects with primary angle-closure disease and 80 controls were recruited. All participants underwent ASOCT, and customized software was used to measure LV, defined as the perpendicular distance between the anterior pole of the lens and a horizontal line joining the two scleral spurs. A-scan biometry was used to measure lens thickness (LT) and to calculate lens position (LP) and relative lens position (RLP).

Results

Eyes with angle closure had significantly shallower anterior chamber depth (ACD), shorter axial length, greater LV and LT (p <0.001 for all), and anteriorly positioned lenses (LP, p < 0.001; RLP, p = 0.019). After multivariate analysis adjusted for age, gender, ACD, LT, and RLP, increased LV was significantly associated with angle closure (odds ratio [OR] 24.2; 95 % confidence interval [CI], 2.3–250.5, comparing lowest with highest quartile), but no association was found for LT (OR 2.59; 95 %CI, 0.48–13.85). In a sub-analysis evaluating the effect of LT on LV, LV was significantly greater in both the angle-closure group with thinner lens (LT ≤ 4.91 mm) and angle-closure group with thicker lens (LT > 4.91 mm) compared to normal controls (p < 0.001 for both).

Conclusions

In Japanese eyes, LV was independently associated with angle closure. These results corroborate the recent findings from Singapore on LV as a risk factor for angle closure.

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Fig. 1

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Authors and Affiliations

  1. Ozaki Eye Hospital, Hyuga, Japan

    Mineo Ozaki

  2. Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Singapore

    Monisha E. Nongpiur & Tin Aung

  3. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Tin Aung

  4. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

    Mingguang He

  5. Mizoguchi Eye Clinic, Sasebo, Japan

    Takanori Mizoguchi

  6. Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Tin Aung

Authors
  1. Mineo Ozaki
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  2. Monisha E. Nongpiur
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  3. Tin Aung
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  4. Mingguang He
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  5. Takanori Mizoguchi
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Corresponding author

Correspondence to Tin Aung.

Additional information

Mineo Ozaki and Monisha E. Nongpiur are joint first authors.

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Ozaki, M., Nongpiur, M.E., Aung, T. et al. Increased lens vault as a risk factor for angle closure: confirmation in a Japanese population. Graefes Arch Clin Exp Ophthalmol 250, 1863–1868 (2012). https://doi.org/10.1007/s00417-012-2011-y

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  • DOI: https://doi.org/10.1007/s00417-012-2011-y

Keywords

  • Lens vault
  • Anterior segment optical coherence tomography
  • Angle closure glaucoma