Abstract
Background
To determine whether there is a significant correlation between the pulse-wave analysis in the optic nerve head circulation determined by laser speckle flowgraphy (LSFG), and brachial–ankle pulse wave velocity (baPVW), carotid intima–media thickness (IMT), and age.
Methods
Thirty-three patients who visited the Vascular Function Section in our hospital were included. Age was 57.3 ± 12.6 years, with a range from 29 to 80 years. baPVW, carotid IMT, and pulse wave analysis in optic nerve head circulation using LSFG were conducted on subjects, and this parameter is named blowout time (BOT). The following items were analyzed as other systemic parameters: age, blood pressure, pulse pressure, heart rate, body mass index, and mean arterial blood pressure; other ocular parameters were intraocular pressure and ocular perfusion pressure. Pearson’s correlation coefficients were used to determine the relationship between the BOT, baPWV, IMT, age, and other parameters. In addition, multiple regression analysis was used to determine independent factors for age.
Results
BOT was significantly correlated with age (r = −0.85, P <0.0001), pulse pressure (r = −0.36, P = 0.04), baPWV (r = −0.72, P <0.0001), and IMT (r = −0.64, P < 0.0001). The result of multiple regression analysis showed that baPWV (odds ratio = 0.93, 95% confidence interval = 0.03–1.82 P = 0.04) and BOT (−2.26, −3.27 to −1.26, <0.0001) were independent contribution factors to age.
Conclusions
Our results confirmed measurements of BOT in the optic nerve head can be a useful method for determinin g whether early atherosclerotic changes are present in the optic nerve head circulation.
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Acknowledgments
There was no sponsorship or other support for this study. The authors have no financial conflicts of interest. Involved in design and conduct of this study (T.S., M.T.); involved in collection, management, analysis, and interpretation of the data (T.S., M.T); involved in preparation, review, or approval of the manuscript (T.S., M.T., Y.H., T.M ). The institutional review board of Toho University Sakura Medical Center approved the study, and we began research after obtaining informed consent from all participants in accordance with the Declaration of Helsinki. We had no statistical consultation or assistance.
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Shiba, T., Takahashi, M., Hori, Y. et al. Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age. Graefes Arch Clin Exp Ophthalmol 250, 1275–1281 (2012). https://doi.org/10.1007/s00417-012-1952-5
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DOI: https://doi.org/10.1007/s00417-012-1952-5