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Retinal sensitivity after resolution of the macular edema associated with retinal vein occlusion

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To study the correlation of retinal sensitivity with both morphologic changes in the macula and status of retinal capillary perfusion, after resolution of the macular edema associated with retinal vein occlusion (RVO).

Methods

Retinal sensitivity in the macular area was examined with the Micro Perimeter 1 in 24 eyes after resolution of the macular edema associated with RVO. Using spectral-domain optical coherence tomography, 6 mm × 6 mm areas of macula were examined with 256 sequential horizontal scans. Condition of the photoreceptor layer was evaluated depending upon detection of the junctions between inner and outer segments of the photoreceptors (IS/OS). Fluorescein angiography was performed in 19 eyes.

Results

Mean retinal sensitivity on the affected side of the retina was significantly decreased (p < 0.001). On the affected side, the mean retinal sensitivity within the area of deteriorated IS/OS was significantly less (3.8 ± 4.8 dB) than that within areas with complete IS/OS (10.1 ± 6.4 dB, p < 0.001). Mean retinal sensitivity within nonperfused areas was extremely low (0.3 ± 1.3 dB), compared with that in perfused retina (10.9 ± 5.9 dB, p < 0.001). In eyes with a broken foveal capillary ring (FCR), the marked decline in retinal sensitivity was seen within the area where the FCR was broken; this was not seen in eyes with an intact FCR.

Conclusion

Retinal function was decreased markedly in areas with a damaged photoreceptor layer due to RVO, and was lethally decreased within nonperfused areas. Due to the various limitations of the current study, including implementation of fluorescein angiography in limited number of eyes, wide range of follow-up, and heterogeneity of pretreatments, further prospective studies are necessary to confirm the current findings.

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References

  1. The Branch Vein Occlusion Study Group (1984) Argon laser photocoagulation for macular edema in branch vein occlusion. Am J Ophthalmol 98:271–282

    Google Scholar 

  2. Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM (1996) Prognostic factors for retinal vein occlusion: prospective study of 175 cases. Ophthalmol 103:551–560

    CAS  Google Scholar 

  3. Arnarsson A, Stefánsson E (2000) Laser treatment and the mechanism of edema reduction in branch retinal vein occlusion. Invest Ophthalmol Vis Sci 41:877–879

    PubMed  CAS  Google Scholar 

  4. Esrick E, Subramanian ML, Heier JS, Devaiah AK, Topping TM, Frederick AR, Morley MG (2005) Multiple laser treatments for macular edema attributable to branch retinal vein occlusion. Am J Ophthalmol 139:653–657

    Article  PubMed  Google Scholar 

  5. Ohashi H, Oh H, Nishiwaki H, Nonaka A, Takagi H (2004) Delayed absorption of macular edema accompanying serous retinal detachment after grid laser treatment in patients with branch retinal vein occlusion. Ophthalmol 111:2050–2056

    Article  Google Scholar 

  6. Horio N, Horiguchi M (2005) Effect of arteriovenous sheathotomy on retinal blood flow and macular edema in patients with branch retinal vein occlusion. Am J Ophthalmol 139:739–740

    Article  PubMed  Google Scholar 

  7. Mandelcorn MS, Nrusimhadevara RK (2004) Internal limiting membrane peeling for decompression of macular edema in retinal vein occlusion: a report of 14 cases. Retina 24:348–355

    Article  PubMed  Google Scholar 

  8. Tsujikawa A, Fujihara M, Iwawaki T, Yamamoto K, Kurimoto Y (2005) Triamcinolone acetonide with vitrectomy for treatment of macular edema associated with branch retinal vein occlusion. Retina 25:861–867

    Article  PubMed  Google Scholar 

  9. Cekic O, Chang S, Tseng JJ, Barile GR, Del Priore LV, Weissman H, Schiff WM, Ober MD (2005) Intravitreal triamcinolone injection for treatment of macular edema secondary to branch retinal vein occlusion. Retina 25:851–855

    Article  PubMed  Google Scholar 

  10. Chen SD, Sundaram V, Lochhead J, Patel CK (2006) Intravitreal triamcinolone for the treatment of ischemic macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 141:876–883

    Article  PubMed  CAS  Google Scholar 

  11. Goff MJ, Jumper JM, Yang SS, Fu AD, Johnson RN, McDonald HR, Ai E (2006) Intravitreal triamcinolone acetonide treatment of macular edema associated with central retinal vein occlusion. Retina 26:896–901

    Article  PubMed  Google Scholar 

  12. Karacorlu M, Ozdemir H, Karacorlu SA (2005) Resolution of serous macular detachment after intravitreal triamcinolone acetonide treatment of patients with branch retinal vein occlusion. Retina 25:856–860

    Article  PubMed  Google Scholar 

  13. Ozdek SC, Aydin B, Gürelik G, Bahceci U, Hasanreisoğlu B (2005) Effects of intravitreal triamcinolone injection on macular edema and visual prognosis in central retinal vein occlusion. Int Ophthalmol 26:27–34

    Article  PubMed  Google Scholar 

  14. Williamson TH, O’Donnell A (2005) Intravitreal triamcinolone acetonide for cystoid macular edema in nonischemic central retinal vein occlusion. Am J Ophthalmol 139:860–866

    Article  PubMed  CAS  Google Scholar 

  15. Hsu J, Kaiser RS, Sivalingam A, Abraham P, Fineman MS, Samuel MA, Vander JF, Regillo CD, Ho AC (2007) Intravitreal bevacizumab (Avastin) in central retinal vein occlusion. Retina 27:1013–1019

    Article  PubMed  Google Scholar 

  16. Iturralde D, Spaide RF, Meyerle CB, Klancnik JM, Yannuzzi LA, Fisher YL, Sorenson J, Slakter JS, Freund KB, Cooney M, Fine HF (2006) Intravitreal bevacizumab (Avastin) treatment of macular edema in central retinal vein occlusion: a short-term study. Retina 26:279–284

    Article  PubMed  Google Scholar 

  17. Jaissle GB, Leitritz M, Gelisken F, Ziemssen F, Bartz-Schmidt KU, Szurman P (2009) One-year results after intravitreal bevacizumab therapy for macular edema secondary to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 247:27–33

    Article  PubMed  CAS  Google Scholar 

  18. Kreutzer TC, Alge CS, Wolf AH, Kook D, Burger J, Strauss R, Kunze C, Haritoglou C, Kampik A, Priglinger S (2008) Intravitreal bevacizumab for the treatment of macular oedema secondary to branch retinal vein occlusion. Br J Ophthalmol 92:351–355

    Article  PubMed  CAS  Google Scholar 

  19. Kriechbaum K, Michels S, Prager F, Georgopoulos M, Funk M, Geitzenauer W, Schmidt-Erfurth U (2008) Intravitreal Avastin for macular oedema secondary to retinal vein occlusion: a prospective study. Br J Ophthalmol 92:518–522

    Article  PubMed  CAS  Google Scholar 

  20. Pai SA, Shetty R, Vijayan PB, Venkatasubramaniam G, Yadav NK, Shetty BK, Babu RB, Narayana KM (2007) Clinical, anatomic, and electrophysiologic evaluation following intravitreal bevacizumab for macular edema in retinal vein occlusion. Am J Ophthalmol 143:601–606

    Article  PubMed  CAS  Google Scholar 

  21. Rosenfeld PJ, Fung AE, Puliafito CA (2005) Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema from central retinal vein occlusion. Ophthalmic Surg Lasers Imaging 36:336–339

    PubMed  Google Scholar 

  22. Ota M, Tsujikawa A, Kita M, Miyamoto K, Sakamoto A, Yamaike N, Kotera Y, Yoshimura N (2008) Integrity of foveal photoreceptor layer in central retinal vein occlusion. Retina 28:1502–1508

    Article  PubMed  Google Scholar 

  23. Ota M, Tsujikawa A, Murakami T, Kita M, Miyamoto K, Sakamoto A, Yamaike N, Yoshimura N (2007) Association between integrity of foveal photoreceptor layer and visual acuity in branch retinal vein occlusion. Br J Ophthalmol 91:1644–1649

    Article  PubMed  Google Scholar 

  24. Ota M, Tsujikawa A, Murakami T, Yamaike N, Sakamoto A, Kotera Y, Miyamoto K, Kita M, Yoshimura N (2008) Foveal photoreceptor layer in eyes with persistent cystoid macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 145:273–280

    Article  PubMed  Google Scholar 

  25. Yamaike N, Tsujikawa A, Ota M, Sakamoto A, Kotera Y, Kita M, Miyamoto K, Yoshimura N, Hangai M (2008) Three-dimensional imaging of cystoid macular edema in retinal vein occlusion. Ophthalmol 115:355.e2–362.e2

    Article  Google Scholar 

  26. Ojima Y, Tsujikawa A, Hangai M, Nakanishi H, Inoue R, Sakamoto A, Yoshimura N (2008) Retinal sensitivity measured with the micro perimeter 1 after resolution of central serous chorioretinopathy. Am J Ophthalmol 146:77–84

    Article  PubMed  Google Scholar 

  27. Rohrschneider K, Springer C, Bültmann S, Völcker HE (2005) Microperimetry—comparison between the micro perimeter 1 and scanning laser ophthalmoscope–fundus perimetry. Am J Ophthalmol 139:125–134

    Article  PubMed  Google Scholar 

  28. Springer C, Bültmann S, Völcker HE, Rohrschneider K (2005) Fundus perimetry with the Micro Perimeter 1 in normal individuals: comparison with conventional threshold perimetry. Ophthalmol 112:848–854

    Article  Google Scholar 

  29. Yamaike N, Tsujikawa A, Sakamoto A, Ota M, Kotera Y, Miyamoto K, Kita M, Yoshimura N (2009) Retinal sensitivity after intravitreal injection of bevacizumab for the treatment of macular edema secondary to retinal vein occlusion. Retina 29:757–767

    Article  PubMed  Google Scholar 

  30. Imasawa M, Iijima H, Morimoto T (2001) Perimetric sensitivity and retinal thickness in eyes with macular edema resulting from branch retinal vein occlusion. Am J Ophthalmol 131:55–60

    Article  PubMed  CAS  Google Scholar 

  31. Kriechbaum K, Prager F, Geitzenauer W, Benesch T, Schutze C, Simader C, Schmidt-Erfurth U (2009) Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year. Ophthalmol 116:2415–2421

    Article  Google Scholar 

  32. Okada K, Yamamoto S, Mizunoya S, Hoshino A, Arai M, Takatsuna Y (2006) Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema. Eye (Lond) 20:805–809

    Article  CAS  Google Scholar 

  33. Unoki N, Nishijima K, Sakamoto A, Kita M, Watanabe D, Hangai M, Kimura T, Kawagoe N, Ohta M, Yoshimura N (2007) Retinal sensitivity loss and structural disturbance in areas of capillary nonperfusion of eyes with diabetic retinopathy. Am J Ophthalmol 144:755–760

    Article  PubMed  Google Scholar 

  34. Vujosevic S, Midena E, Pilotto E, Radin PP, Chiesa L, Cavarzeran F (2006) Diabetic macular edema: correlation between microperimetry and optical coherence tomography findings. Invest Ophthalmol Vis Sci 47:3044–3051

    Article  PubMed  Google Scholar 

  35. Yamaike N, Kita M, Tsujikawa A, Miyamoto K, Yoshimura N (2007) Perimetric sensitivity with the Micro Perimeter 1 and retinal thickness in patients with branch retinal vein occlusion. Am J Ophthalmol 143:342–344

    Article  PubMed  Google Scholar 

  36. Chee CK, Flanagan DW (1993) Visual field loss with capillary non-perfusion in preproliferative and early proliferative diabetic retinopathy. Br J Ophthalmol 77:726–730

    Article  PubMed  CAS  Google Scholar 

  37. Bell JA, Feldon SE (1984) Retinal microangiopathy Correlation of OCTOPUS perimetry with fluorescein angiography. Arch Ophthalmol 102:1294–1298

    Article  PubMed  CAS  Google Scholar 

  38. Finkelstein D (1992) Ischemic macular edema Recognition and favorable natural history in branch vein occlusion. Arch Ophthalmol 110:1427–1434

    Article  PubMed  CAS  Google Scholar 

  39. Chung EJ, Hong YT, Lee SC, Kwon OW, Koh HJ (2008) Prognostic factors for visual outcome after intravitreal bevacizumab for macular edema due to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 246:1241–1247

    Article  PubMed  CAS  Google Scholar 

  40. Clemett RS, Kohner EM, Hamilton AM (1973) The visual prognosis in retinal branch vein occlusion. Trans Ophthalmol Soc U K 93:523–535

    PubMed  CAS  Google Scholar 

  41. Shilling JS, Jones CA (1984) Retinal branch vein occlusion: a study of argon laser photocoagulation in the treatment of macular oedema. Br J Ophthalmol 68:196–198

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

The authors have no financial interest in the materials or devices mentioned in this article.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan

    Masafumi Ota, Akitaka Tsujikawa, Yumiko Ojima, Kazuaki Miyamoto, Tomoaki Murakami, Ken Ogino, Yumiko Akagi-Kurashige, Yuki Muraoka & Nagahisa Yoshimura

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  1. Masafumi Ota
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  2. Akitaka Tsujikawa
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  3. Yumiko Ojima
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  4. Kazuaki Miyamoto
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Correspondence to Akitaka Tsujikawa.

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Ota, M., Tsujikawa, A., Ojima, Y. et al. Retinal sensitivity after resolution of the macular edema associated with retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 250, 635–644 (2012). https://doi.org/10.1007/s00417-011-1860-0

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  • DOI: https://doi.org/10.1007/s00417-011-1860-0

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