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Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis

  • Inflammatory Disorders
  • Published:
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Abstract

Background

To determine treatment outcome and risk factors for visual loss in Cytomegalovirus (CMV) endotheliitis.

Methods

Retrospective case-note review of all CMV positive endotheliitis patients seen at the Singapore National Eye Center, for demographics, visual acuity (VA), extent of corneal edema, anterior chamber (AC) activity, ocular history, glaucomatous optic neuropathy (GON), and ganciclovir therapy. Outcome measures were VA, corneal edema, and AC activity.

Results

Median age at diagnosis of the 19 patients (21 eyes) was 57 years. Median duration of follow up was 37 months. Sixteen eyes received systemic ganciclovir, and four eyes received ganciclovir gel. The AC inflammation resolved in 19 eyes. The corneal edema resolved in eight eyes, but persisted in 12 eyes. One patient resolved spontaneously. Pre-treatment corneal edema exceeding 75%, older age, GON, and previous corneal graft were risk factors for persistent corneal edema post treatment (P = < 0.001, 0.001, 0.02 and 0.02 respectively, Fisher’s exact test), and VA worse than 6/60.

Conclusions

Anterior chamber inflammation resolves with ganciclovir therapy, but severe pre-treatment corneal edema, older age, previous corneal graft, and GON are associated with a poor visual outcome.

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Authors and Affiliations

  1. Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Soon-Phaik Chee & Aliza Jap

  2. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260, Singapore

    Soon-Phaik Chee

  3. Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Soon-Phaik Chee

  4. Division of Ophthalmology, Changi General Hospital, 2 Simei Street 3, Singapore, 529889, Singapore

    Aliza Jap

Authors
  1. Soon-Phaik Chee
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  2. Aliza Jap
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Correspondence to Soon-Phaik Chee.

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Funding: nil

The authors have full control of all primary data, and agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Chee, SP., Jap, A. Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis. Graefes Arch Clin Exp Ophthalmol 250, 383–389 (2012). https://doi.org/10.1007/s00417-011-1813-7

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  • DOI: https://doi.org/10.1007/s00417-011-1813-7

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