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Use of intravitreal triamcinolone and bevacizumab in Coats' disease with central macular edema

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Abstract

Background

Intravitreal application of triamcinolone and bevacizumab in Coats' disease with macular edema to improve visual outcome.

Methods

Testing of best-corrected visual acuity (BCVA), ophthalmoscopy, optical coherence tomography, fluorescein angiography, 30° perimetry, and full-field electroretinography were performed at initial and follow-up visits. Medical treatment consisted of intravitreal injection of 1.25 mg bevazicumab and 1.25 mg triamcinolone, followed by intravitreal injections of 1.25 mg bevazicumab at weeks 4 and 10. Follow-up was 87 weeks.

Results

Perimetric results, including a temporal absolute scotoma and reduced electroretinographic amplitudes (photopic and scotopic conditions), did not significantly change during the follow-up, but foveal retinal thickness decreased from 505 μm to 212 μm, and BCVA increased from 0.3 at baseline to 1.25 and remained stable during subsequent follow-up.

Conclusions

Combined intravitreal treatment with bevacizumab and triamcinolone resulted in significant decrease of central retinal thickness and improved visual acuity in this case report. Severe local or systemic side-effects were not observed.

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Authors and Affiliations

  1. University Eye Hospital, University Clinics Muenster, Domagkstr. 15, 48129, Muenster, Germany

    Michael R. R. Böhm & Constantin E. Uhlig

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  1. Michael R. R. Böhm
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  2. Constantin E. Uhlig
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Correspondence to Constantin E. Uhlig.

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Böhm, M.R.R., Uhlig, C.E. Use of intravitreal triamcinolone and bevacizumab in Coats' disease with central macular edema. Graefes Arch Clin Exp Ophthalmol 249, 1099–1101 (2011). https://doi.org/10.1007/s00417-011-1629-5

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  • DOI: https://doi.org/10.1007/s00417-011-1629-5

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