Abstract
Background
A 73-year-old patient presented in our clinic with multiple pigmented iris nodules in the left eye. Though asymptomatic, there was a reported increase in size and number of the nodules during the past year.
Methods
Interventional case report describing a biopsy-proven multifocal iris melanoma treated with a palladium-103 plaque to include the entire anterior chamber within the targeted zone. Biopsy was performed utilizing a 25-gauge aspiration-cutter under viscoelastic. The cornea was protected during radiation therapy with the amniotic membrane buffer technique. Evaluation parameters included visual acuity and clinical assessments aided by slit-lamp photography as well as high-frequency ultrasound imaging.
Results
Plaque radiation therapy was well tolerated. Her visual acuity has remained within five letters at 20/25 at 1-year follow-up. Clinical evaluation revealed no evidence of corneal epitheliopathy, iris neovascularization, or visually significant cataract. High-frequency ultrasound imaging revealed a 15% reduction of the tumor’s height. Serial abdominal imaging revealed no metastatic uveal melanoma.
Conclusions
We present a biopsy-proven iris diffuse melanoma treated with palladium-103 plaque radiation therapy. Though the entire anterior segment was irradiated, there were no significant side-effects. Local tumor control was excellent during the first postoperative year.
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Presentation to a conference: This study has not been presented to a conference.
This study was supported by The Eye Cancer Foundation, Inc. (http://eyecancerfoundation.net) from which Dr. Petousis received a fellowship grant.
The authors have full control of all primary data and they agree to allow Graefes Archive for Clinical and Experimental Ophthalmology to review their data upon request
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Petousis, V., Finger, P.T. & Milman, T. Multifocal iris melanoma treated with total anterior segment palladium-103 plaque radiation therapy. Graefes Arch Clin Exp Ophthalmol 249, 937–940 (2011). https://doi.org/10.1007/s00417-010-1590-8
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DOI: https://doi.org/10.1007/s00417-010-1590-8