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Primary intravitreal ranibizumab for adult-onset foveomacular vitelliform dystrophy

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Abstract

Aim

To evaluate the efficacy of intravitreal injections of ranibizumab in adult-onset foveomacular vitelliform dystrophy (AOFVD).

Methods

Six female patients were misdiagnosed in the office as occult choroidal neovascularization due to AMD, and scheduled for 3-monthly intravitreal injections of ranibizumab. One month after the third injection, all patients underwent further examinations consisting of visual acuity, optical coherence tomography, Indocyanine Green angiography, electrophysiological tests (electroretinogram and electrooculogram), and an exhaustive familial history of macular diseases. Cases were followed-up every 6 weeks since the formal diagnose of AOFVD was evidenced.

Results

The mean BCVA improved from 0.36 ± 0.1 at baseline to 0.56 ± 0.1 (p = 0.038). No significant change was evidence in the SD-OCT thickness analysis. Metamorphopsia disappeared completely in all cases after the first injection. No familial history was evidenced.

Conclusions

Ranibizumab intravitreal injections are effective in the short-term BCVA improvement in patients with AOFVD.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital La Fe, Valencia, Spain

    Roberto Gallego-Pinazo, Rosa Dolz-Marco, Diamar Pardo-López & Manuel Díaz-Llopis

  2. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain

    Roberto Gallego-Pinazo & Manuel Díaz-Llopis

  3. Retina & Vitreous Service, Clínica Oftalmológica Centro Caracas, Caracas, Venezuela

    J. Fernando Arevalo

  4. Faculty of Medicine, University of Valencia, Valencia, Spain

    Manuel Díaz-Llopis

Authors
  1. Roberto Gallego-Pinazo
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  2. Rosa Dolz-Marco
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  3. Diamar Pardo-López
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  4. J. Fernando Arevalo
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  5. Manuel Díaz-Llopis
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Corresponding author

Correspondence to Roberto Gallego-Pinazo.

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Gallego-Pinazo, R., Dolz-Marco, R., Pardo-López, D. et al. Primary intravitreal ranibizumab for adult-onset foveomacular vitelliform dystrophy. Graefes Arch Clin Exp Ophthalmol 249, 455–458 (2011). https://doi.org/10.1007/s00417-010-1536-1

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  • DOI: https://doi.org/10.1007/s00417-010-1536-1

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