Abstract
Background
Recent research has suggested that structural significant damage in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) may precede visual field loss. Optical coherence tomography (OCT) has become an important tool which has contributed to earlier and more accurate diagnosis of glaucoma over the past decade. RTVue OCT was the first frequency-domain OCT (FD-OCT) device to offer comprehensive glaucoma analysis including an RNFL thickness map and optic disc morphology. The aim of this study was to evaluate and compare the performance of FD-OCT for the detection of early and advanced glaucoma from normal eyes.
Methods
This was a cross-sectional study consisting of 63 normal eyes, and 37 with early and 41 with advanced glaucoma. All patients underwent RNFL thickness and ONH parameter measurements on the RTVue OCT. Glaucoma variables obtained from RTVue OCT were compared between the groups. Discriminating power for early glaucoma detection was expressed by using the analyses of area under the receiver operating characteristic curves (AUCs).
Results
All RNFL thickness and ONH parameters but disc area showed significant differences between the normal and the glaucoma groups, and the highest AUCs for RNFL thickness was average thickness (AUC = 0.816) and for ONH parameters was cup/disc vertical ratio (AUC = 0.782). They were the best parameters for discriminating normal from early glaucomatous eyes.
Conclusions
Frequency-domain OCT (RTVue OCT) may offer comprehensive analysis for RNFL thickness and ONH, which showed good diagnostic ability in distinguishing normal from glaucomatous eyes.
Similar content being viewed by others
References
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA (2002) The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120:714–720
Zangwill LM, Weinreb RN, Beiser JA, Berry CC, Cioffi GA, Coleman AL, Trick G, Liebmann JM, Brandt JD, Piltz-Seymour JR, Dirkes KA, Vega S, Kass MA, Gordon MO (2005) Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. Arch Ophthalmol 123:1188–1197
Ervin JC, Lemij HG, Mills RP, Quigley HA, Thompson HW, Burgoyne CF (2002) Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomography in the LSU Experimental Glaucoma (LEG) Study. Ophthalmology 109:467–481
Mohammadi K, Bowd C, Weinreb RN, Medeiros FA, Sample PA, Zangwill LM (2004) Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss. Am J Ophthalmol 138:592–601
Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS (2005) Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol 139:39–43
Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna R Jr, Weinreb RN (2005) Evaluation of retinal nerve fiber layer, optic nerve head and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol 139:44–55
Manassakorn A, Nouri-Mahdavi K, Caprioly J (2006) Comparison of retinal nerve fiber layer thickness and optic disc algorithms with optical coherence tomography to detect glaucoma. Am J Ophthalmol 141:105–115
Vizzeri G, Weinreb RN, Gonzalez-Garcia AO, Bowd C, Medeiros FA, Sample PA, Zangwill LM (2009) Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness. Br J Ophthalmol 93:775–781
González-García AO, Vizzeri G, Bowd C, Medeiros FA, Zangwill LM, Weinreb RN (2009) Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements. Am J Ophthalmol 147:1067–1074.e1
Hodapp E (1993) Follow-up of primary open-angle glaucoma. In: Parrish RK, Anderson DR (eds) Clinical decisions in glaucoma. Mosby, St. Louis, pp 84–125
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA (1991) Optical coherence tomography. Science 254:1178–1181
Chen TC, Zeng A, Sun W, Mujat M, de Boer JF (2008) Spectral domain optical coherence tomography and glaucoma. Int Ophthalmol Clin 48:29–45
Nouri-Mahdavi K, Nikkhou K, Hoffman DC, Law SK, Caprioli J (2008) Detection of early glaucoma with optical coherence tomography (StratusOCT). J Glaucoma 17:183–188
Naithani P, Sihota R, Sony P, Dada T, Gupta V, Kondal D, Pandey RM (2007) Evaluation of optical coherence tomography and Heidelberg retinal tomography parameters in detecting early and moderate glaucoma. Invest Ophthalmol Vis Sci 48:3138–3145
Badalà F, Nouri-Mahdavi K, Raoof DA, Leeprechanon N, Law SK, Caprioli J (2007) Optic disk and nerve fiber layer imaging to detect glaucoma. Am J Ophthalmol 144:724–732
Schmidt-Erfurth U, Leitgeb RA, Michels S, Povazay B, Sacu S, Hermann B, Ahlers C, Sattmann H, Scholda C, Fercher AF, Drexler W (2005) Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. Invest Ophthalmol Vis Sci 46:3393–3402
Chen TC, Cense B, Pierce MC, Nassif N, Park BH, Yun SH, White BR, Bouma BE, Tearney GJ, de Boer JF (2005) Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. Arch Ophthalmol 123:1715–1720
Leung CK, Chan WM, Hui YL, Yung WH, Woo J, Tsang MK, Tse KK (2005) Analysis of retinal nerve fiber layer and optic nerve head in glaucoma with different reference plane offsets, using optical coherence tomography. Invest Ophthalmol Vis Sci 46:891–899
Bourne RR, Medeiros FA, Bowd C, Jahanbakhsh K, Zangwill LM, Weinreb RN (2005) Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments. Invest Ophthalmol Vis Sci 46:1280–1285
Budenz DL, Michael A, Chang RT, McSoley J, Katz J (2005) Sensitivity and specificity of the StratusOCT for perimetric glaucoma. Ophthalmology 112:3–9
Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS (2005) Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol 139:39–43
Author information
Authors and Affiliations
Corresponding author
Additional information
No financial interests in any of the products mentioned in the study.
The authors have full control of all primary data, and agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review data upon request.
Rights and permissions
About this article
Cite this article
Li, S., Wang, X., Li, S. et al. Evaluation of optic nerve head and retinal nerve fiber layer in early and advance glaucoma using frequency-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 248, 429–434 (2010). https://doi.org/10.1007/s00417-009-1241-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-009-1241-0