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Intraocular pressure and superior ophthalmic vein blood flow velocity in Graves’ orbitopathy: relation with the clinical features

  • Oculoplastics and Orbit
  • Published:
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Abstract

Background

The aim of this study is to evaluate the association of intraocular pressure (IOP) and superior ophthalmic vein blood flow velocity (SOV-BFV) with the clinical features of Graves’ orbitopathy.

Methods

During the 2002-2007 period, 66 eyes of 34 Graves’ orbitopathy cases were classified as mild, moderate and severe orbital disease, and evaluated according to their clinical features as: i)type 1 vs type 2 cases, and ii) cases with or without dysthyroid optic neuropathy. In all patients, a full ophthalmic examination including IOP and Hertel measurements was performed. SOV-BFV was analyzed with color Doppler sonography.

Results

The Hertel value, IOP in primary and upgaze position were higher, and SOV-BFV was lower in moderate and severe Graves’ orbitopathy cases that showed statistical significance from mild cases, and controls (p = 0.001). Moderate and severe Graves’ orbitopathy cases showed comparable Hertel measures and IOP in primary and upgaze position (p = 0.39); however, SOV-BFV was significantly lower in severe cases when compared to moderate cases (p = 0.001).This study demonstrated statistically significant negative correlation between IOP in both primary (r = 0.43,p = 0.008) and upgaze position (r = 0.51,p = 0.002), and SOV-BFV. Additionally, statistically significant positive correlation was detected between Hertel values and SOV-BFV(r = 0.402,p = 0.007).There was a statistical difference between type 1 and 2 cases in Hertel values(p = 0.006), IOP in upgaze position (p = 0.026) and SOV-BFV (p = 0.003). SOV-BFV of the eyes showing dysthyroid optic neuropathy was statistically lower than eyes without dysthyroid optic neuropathy (p = 0.006).

Conclusions

IOP and SOV-BFV have significant association with the clinical features of Graves’ orbitopathy. The decrease in SOV-BFV increases the severity of Graves’ orbitopathy, and may have a role in the clinical course of dysthyroid optic neuropathy.

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Authors and Affiliations

  1. Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey

    Onur Konuk & Mehmet Unal

  2. Department of Ophthalmology, Kirikkale University School of Medicine, Kirikkale, Turkey

    Zafer Onaran

  3. Department of Radiology, Gazi University School of Medicine, Ankara, Turkey

    Suna Ozhan Oktar & Cem Yucel

  4. 441. cadde 437. sokak 3-3 Birlik Mah, TR-06610, Cankaya, Ankara, Turkey

    Onur Konuk

Authors
  1. Onur Konuk
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  2. Zafer Onaran
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  3. Suna Ozhan Oktar
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  4. Cem Yucel
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  5. Mehmet Unal
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Correspondence to Onur Konuk.

Additional information

None of the authors has a financial or proprietary interest in any method or material mentioned.

The authors have full control of all primary data ,and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request

This study was presented in the 25th European Society of Ophthalmic Plastic and Reconstructive Surgery Meeting, 13 - 16 September, 2007, Ljubljana, Slovenia

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Konuk, O., Onaran, Z., Ozhan Oktar, S. et al. Intraocular pressure and superior ophthalmic vein blood flow velocity in Graves’ orbitopathy: relation with the clinical features. Graefes Arch Clin Exp Ophthalmol 247, 1555–1559 (2009). https://doi.org/10.1007/s00417-009-1144-0

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  • DOI: https://doi.org/10.1007/s00417-009-1144-0

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