Skip to main content
SpringerLink
Log in

Botulinum toxin A injection for primary and recurrent chalazia

  • Oculoplastics and Orbit
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To study the efficacy and safety of subcutaneous botulinum toxin A injections in the treatment of primary and recurrent chalazia.

Methods

Prospective, placebo-controlled consecutive case-series trial. Sixty three patients were divided into two groups: group 1 consisting of 32 patients previously diagnosed with and treated for primary or recurrent chalazia with 2–5 international units (IU) in 0.2–0.5 ml of preserved saline solution of botulinum toxin injection, and group 2 consisting of 31 patients receiving placebo. The main outcome measures were localization and duration of the disease, size of chalazion before and after treatment, clinical resolution of chalazion, time to resolution, and complications of treatment.

Results

There was a clinically and statistically significant between-group difference in the rate of therapeutic success and post-therapeutic chalazion regression, but not in the rate of complications.

Conclusions

Botulinum toxin A injection is effective and safe treatment for primary and recurrent chalazia. Lesion regression that did not respond to the average of two injections would benefit more from surgical excision or systemic antibiotic therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dhaliwal U, Arora VK, Singh N, Bhatia A (2004) Cytopathology of chalazia. Diagn Cytopathol 31(2):118–122. doi:10.1002/dc.20092

    Article  PubMed  Google Scholar 

  2. Lempert SL, Jenkins MS, Brown SI (1979) Chalazia and rosacea. Arch Ophthalmol 97(9):1652–1653 Sep

    PubMed  CAS  Google Scholar 

  3. Dua HS, Nilawar DV (1982) Nonsurgical therapy of chalazion. Am J Ophthalmol 94:424–425

    PubMed  CAS  Google Scholar 

  4. Perry HD, Serniuk RA (1980) Conservative treatment of chalazia. Ophthalmology 87:18–21

    Google Scholar 

  5. Pizzarello LD, Jakobiec FA, Hofeldt AJ et al (1978) Intralesional corticosteroid therapy of chalazia. Am J Ophthalmol 85:818

    PubMed  CAS  Google Scholar 

  6. Watson AP, Austin DJ (1984) Treatment of chalazion with injection of a steroid suspension. Br J Ophthalmol 68:833. doi:10.1136/bjo.68.11.833

    Article  PubMed  CAS  Google Scholar 

  7. Ben Simon GJ, Huang L, Nakra T et al (2005) Intralesional triamcinolone acetonide injection for primary and recurrent chalazia: is it really effective? Ophthalmology 112:913–917. doi:10.1016/j.ophtha.2004.11.037

    Article  PubMed  Google Scholar 

  8. Epstein GA, Putterman AM (1988) Combined excision and drainage with intralesional corticosteroid injection in the treatment of chronic chalazia. Arch Ophthalmol 106:514–516

    PubMed  CAS  Google Scholar 

  9. Chung CF, Lai JS, Li PS et al (2006) Subcutaneous extralesional triamcinolone acetonide injection versus conservative management in the treatment of chalazion. Hong Kong Med J 12(4):278–281

    PubMed  CAS  Google Scholar 

  10. Dutton JJ, Fowler AM (2007) Botulinum toxin in ophthalmology. Surv Ophthalmol 52(1):13–31. doi:10.1016/j.survophthal.2006.10.003

    Article  PubMed  Google Scholar 

  11. Turton K, Chaddock JA, Acharya KR et al (2002) Botulinum and tetanus neurotoxin structure, function and therapeutic utility. Trends Biochem Sci 27:552–558. doi:10.1016/S0968–0004(02)02177–1

    Article  PubMed  CAS  Google Scholar 

  12. Glogau RG (2002) Review of botulinum toxin for hyperhidrosis and cosmetic purposes. Clin J Pain 18:191–197. doi:10.1097/00002508–200211001–00012

    Article  Google Scholar 

  13. Kinkelin I, Hind M, Naumann M et al (2000) Effective treatment of frontal hyperhidrosis with botulinum toxin A. Br J Dermatol 143:824–827. doi:10.1046/j.1365–2133.2000.03839.x

    Article  PubMed  CAS  Google Scholar 

  14. Perra MT, Serra A, Sirigu P, Turno F (1996) Histochemical demonstration of acetyl cholinesterase activity in human meibomian gland. Eur J Histochem 40(19):39–44

    PubMed  CAS  Google Scholar 

  15. Aisa J, Lahoz M, Serrano P, Pérez-Castejón MC, Junquera C, Martinez-Ciriano MC, Pes N, Vera-Gil A (2001) Acetylcholinesterase-positive and paraformaldehyde-induced-fluorescence-positive innervation in the upper eyelid of the sheep (Ovis aries). Histol Histopathol 16(2):487–496

    PubMed  CAS  Google Scholar 

  16. Chung CW, Tigges M, Stone RA (1996) Peptidergic innervation of the primate meibomian gland. Invest Ophthalmol Vis Sci 37(1):238–245

    PubMed  CAS  Google Scholar 

  17. Prasad S, Gupta AK (1992) Subconjunctival total excision in the treatment of the chronic chalazia. Indian J Ophthalmol 40:103–106

    PubMed  CAS  Google Scholar 

  18. Thomas EL, Laborde RP (1986) Retinal and choroidal vascular occlusion following intralesional corticosteroid injection of chalazion. Ophthalmology 93:405–407

    PubMed  CAS  Google Scholar 

  19. Procope JA, Kidwell ED Jr (1996) Delayed postoperative hemorrhage complicating chalazion surgery. J Natl Med Assoc 86:865–866

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Department of Ophthalmology, University Hospital “Sestre milordnice”, Vinogradska 29, 10 000, Zagreb, Croatia

    Tamara Knezevic, Renata Ivekovic, Jasna Pavicic Astalos, Katia Novak Laus, Zdravko Mandic & Aljosa Matejcic

Authors
  1. Tamara Knezevic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Renata Ivekovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jasna Pavicic Astalos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katia Novak Laus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zdravko Mandic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Aljosa Matejcic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Renata Ivekovic.

Additional information

The authors have no financial interests in this study. The authors have full control of all primary data and they allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review data of study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Knezevic, T., Ivekovic, R., Pavicic Astalos, J. et al. Botulinum toxin A injection for primary and recurrent chalazia. Graefes Arch Clin Exp Ophthalmol 247, 789–794 (2009). https://doi.org/10.1007/s00417-008-0992-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-008-0992-3

Keywords

Search

Navigation