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Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): 18-month experience with telemedicine screening

Graefe's Archive for Clinical and Experimental Ophthalmology volume 247, pages 129–136 (2009)Cite this article

Abstract

Purpose

To report the 18-month experience of the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) telemedicine initiative.

Design

Retrospective analysis of the SUNDROP archival data between 1 December 2005 and 30 May 2007, evaluating this new diagnostic technology for ROP screening.

Participants

All 97 consecutively enrolled infants in the SUNDROP network.

Methods

All patients were screened using the RetCam II, and evaluated by the SUNDROP reading center at Stanford University. Nurses were trained to obtain five images in each eye. All patients were screened by an ophthalmologist trained in diagnosing ROP within 1 week of discharge from the hospital.

Main outcome measures

Outcomes included referral-warranted disease, need for treatment, and anatomic outcomes. Referral-warranted disease was defined as any Early Treatment Retinopathy of Prematurity Disease Type 2 or greater, threshold disease, any plus disease, and any stage 4 or higher disease.

Results

In the initial 18-month period, the SUNDROP telemedicine screening initiative has not missed any referral-warranted disease for ROP. A total of 97 infants (194 eyes) were enrolled, resulting in 443 unique examinations and 4,929 unique images. The mean birth weight of the infants was 1,186.9 grams, with a mean gestational age at birth of 28.9 weeks. Seven infants were identified with referral-warranted disease; six patients underwent laser photocoagulation and completely regressed. The one remaining patient regressed spontaneously, and did not require intervention. Calculated sensitivity and specificity was 100% and 98.9% respectively. No patient progressed to retinal detachment or other adverse outcome. Inadequate exposure, artifact, poor visualization of the periphery, and lack of a complete standardized image set in some patients were identified as areas requiring further assessment.

Conclusions

The SUNDROP telemedicine screening initiative for ROP has proven to have a high degree of sensitivity and specificity for identification of referral-warranted disease. Training was easily implemented. All cases of referral-warranted disease were captured. There were no adverse outcomes.

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Affiliations

  1. Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA

    Ruwan A. Silva, Yohko Murakami, Atul Jain, Jarel Gandhi, Eleonora M. Lad & Darius M. Moshfeghi

  2. Stanford University, 1225 Crane St., Ste. 202, Menlo Park, CA, 94025, USA

    Darius M. Moshfeghi

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  1. Ruwan A. Silva
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  2. Yohko Murakami
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  3. Atul Jain
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Correspondence to Darius M. Moshfeghi.

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Financial Disclosure: DMM serves on the Scientific Advisory Board for Clarity Medical Systems (Pleasanton, CA, USA), the manufacturer of the RetCam, RetCam II, and Shuttle cameras.

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Silva, R.A., Murakami, Y., Jain, A. et al. Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): 18-month experience with telemedicine screening. Graefes Arch Clin Exp Ophthalmol 247, 129–136 (2009). https://doi.org/10.1007/s00417-008-0943-z

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  • DOI: https://doi.org/10.1007/s00417-008-0943-z

Keywords

  • Retinopathy of prematurity
  • ROP
  • Telemedicine
  • Retrospective study