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Lutein prevents cataract development and progression in diabetic rats

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Abstract

Background

Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia. It is often associated with complications, such as cataracts. Cataract, characterized by cloudiness or opacity of the eye lens, is the leading cause of blindness worldwide.

Methods

The present study investigated the effect of lutein, alone or combined with insulin on the progression of eye lens opacities in streptozotocin-diabetic rats for a period of 12 weeks. Tissue markers of oxidative stress were also determined at the end of the experiment.

Results

Herein we demonstrate that lutein treatment prevents the development and progression of cataracts (0 eyes with mature cataract, and ten out of 16 eyes with clear lenses in the lutein-treated diabetic animals group, vs. seven and three eyes in the non-treated diabetic group, respectively). Lipid peroxidation is significantly increased in diabetic lens (up to three-fold); lutein and insulin, alone or in combination, are able to prevent this alteration. Only insulin and lutein together could prevent the diabetes-induced decrease of glutathione content.

Conclusions

The combined treatment with lutein and insulin is useful in preventing the development of cataracts in streptozotocin-induced diabetic rats, supporting its utility in diabetes management, especially when a tight metabolic control is difficult to achieve.

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Acknowledgements

This study was partially supported with funds from Fundación San Pablo-CEU. Thanks are also indebted to Kemin Health L.C. for its support.

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Authors and Affiliations

  1. Departamento de Fisiología, Farmacología & Toxicología, Universidad CEU-Cardenal Herrera, Avda. Seminario s/n, 46113, Moncada, Valencia, Spain

    Emma Arnal, María Miranda, Inmaculada Almansa, María Muriach, Jorge M. Barcia, Francisco J. Romero & Francisco Bosch-Morell

  2. Fundación Oftalmológica del Mediterráneo, Valencia, Spain

    Francisco J. Romero & Francisco Bosch-Morell

  3. Departament de Cirurgia, Universitat de València, Valencia, Spain

    Manuel Diaz-Llopis

Authors
  1. Emma Arnal
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  2. María Miranda
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  3. Inmaculada Almansa
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  4. María Muriach
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  5. Jorge M. Barcia
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  6. Francisco J. Romero
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  7. Manuel Diaz-Llopis
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  8. Francisco Bosch-Morell
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Corresponding author

Correspondence to Francisco J. Romero.

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Arnal, E., Miranda, M., Almansa, I. et al. Lutein prevents cataract development and progression in diabetic rats. Graefes Arch Clin Exp Ophthalmol 247, 115–120 (2009). https://doi.org/10.1007/s00417-008-0935-z

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  • DOI: https://doi.org/10.1007/s00417-008-0935-z

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