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Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy

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Abstract

Background

To report a case of a secondary plasmacytoma of the choroid.

Methods

Interventional case report with cytopathologic correlation.

Results

A 61-year-old male with a breast nodule and a 2-year history of multiple myeloma developed blurred vision and was found to have three confluent, ill-defined areas of choroidal thickening in the left eye. Cytopathology and immunohistochemistry of a transocular fine-needle aspiration biopsy of the largest lesion revealed atypical plasma cells diagnostic of plasmacytoma. Following external beam radiotherapy the choroidal tumors resolved completely.

Conclusion

Secondary plasmacytoma, despite its rarity, should be included in the differential diagnosis of amelanotic choroidal tumors, particularly in patients with multiple myeloma. Radiotherapy is an effective treatment.

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Author information

Authors and Affiliations

  1. Ocular Oncology Service Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, USA

    Melis Palamar, Carol L. Shields, Fariba Ghassemi & Jerry A. Shields

  2. Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA

    Hormoz Ehya

  3. Ocular Oncology Service, Suite 1440, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA, 19107, USA

    Carol L. Shields

Authors
  1. Melis Palamar
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  2. Carol L. Shields
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  3. Fariba Ghassemi
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  4. Hormoz Ehya
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  5. Jerry A. Shields
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Corresponding author

Correspondence to Carol L. Shields.

Additional information

Support provided by the Retina Research Foundation of the Retina Society in Cape Town, South Africa (CLS), the Eye Tumor Research Foundation, Philadelphia, PA, USA (CLS, JAS), Mellon Charitable Giving from the Martha W. Rogers Charitable Trust (CLS), the Paul Kayser International Award of Merit in Retina Research, Houston TX (JAS), and the LuEsther Mertz Retina Research Foundation (CLS).

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Palamar, M., Shields, C.L., Ghassemi, F. et al. Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy. Graefes Arch Clin Exp Ophthalmol 246, 1195–1197 (2008). https://doi.org/10.1007/s00417-008-0804-9

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  • DOI: https://doi.org/10.1007/s00417-008-0804-9

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