Skip to main content

Advertisement

SpringerLink
Log in

Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits

  • Basic Science
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

The aim of this study was to evaluate the mid-term biocompatibility of a new x-shaped implant made of zirconium in an animal model of glaucoma surgery.

Methods

Preoperatively, ultrasound biomicroscopy (UBM), intraocular pressure (IOP) and outflow facility (OF) data were acquired. Upon surgery, one eye was chosen randomly to receive an implant, while the other received none. Ten rabbits went through a 1-, 2-, 3-, 4- and 6-month follow-up. IOP was measured regularly, UBM performed at 1, 3 and 6 months after surgery. At the end of the follow-up, OF was again measured. Histology sections were analyzed.

Results

For both groups IOP control was satisfactory, while OF initially increased at month 1 to resume preoperative values thereafter. Eyes with implants had larger filtration blebs which decreased faster than in eyes without the implant. Drainage vessel density, inflammatory cell number and fibrosis were higher in tissues near the implant.

Conclusions

The zirconium implant initially promoted the positive effects of the surgery (IOP control, OF increase). Nevertheless, after several months, foreign body reactions and fibrosis had occurred on some implants that restrained the early benefit of such a procedure. Modifications of the zirconium implant geometry could enhance the overall success rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Fyodorov SN, Koslov VI, Timoshkina NT et al (1990) Nonpenetrating deep sclerectomy in open angle glaucoma. Ophthalmosurg 3:52–55

    Google Scholar 

  2. Kozlov VI, Bagrov SN, Anisimova SY (1990) Nonpenetrating deep sclerectomy with collagen. Ophthal Surg 3:44–46

    Google Scholar 

  3. Chiou AG, Mermoud A, Underdahl JP, Schnyder CC (1998) An ultrasound biomicroscopic study of eyes after deep sclerectomy with collagen implant. Ophthalmology 105:746–750

    Article  PubMed  CAS  Google Scholar 

  4. Karlen ME, Sanchez E, Schnyder CC, Sickenberg M, Mermoud A (1999) Deep sclerectomy with collagen implant: medium term results. Br J Ophthalmol 83:6–11

    Article  PubMed  CAS  Google Scholar 

  5. Mermoud A, Schnyder CC, Sickenberg M, Chiou AG, Hediger SE, Faggioni R (1999) Comparison of deep sclerectomy with collagen implant and trabeculectomy in open-angle glaucoma. J Cataract Refract Surg 25:323–331

    Article  PubMed  CAS  Google Scholar 

  6. Shaarawy T, Nguyen C, Schnyder C, Mermoud A (2004) Comparative study between deep sclerectomy with and without collagen implant: long-term follow-up. Br J Ophthalmol 88:95–98

    Article  PubMed  CAS  Google Scholar 

  7. Sourdille P, Santiago PY, Ducourneau Y (1999) Non perforating surgery of the trabeculum with reticulated hyaluronic acid implant. J Fr Ophthalmol 22:794–797

    CAS  Google Scholar 

  8. Piconi C, Maccauro G (1999) Zirconia as a ceramic biomaterial. Biomaterials 20:1–25

    Article  PubMed  CAS  Google Scholar 

  9. Seghi R, Denry I, Rosentiel S (1995) Relative fracture toughness and hardness of new dental ceramics. J Prosthet Dent 74:145–150

    Article  PubMed  CAS  Google Scholar 

  10. Guazzato M, Albakri M, Ringer SP, Swain MV (2004) Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part I. Pressable and alumina glass-infiltrated ceramics. Dent Mater 5:441–448

    Article  CAS  Google Scholar 

  11. Schadel A, Thun G, Stork L, Metzla R (1993) Immunodiffusion and immunohistochemical investigations on the reactivity of oxide ceramic middle ear implants. ORL J Otorhinolaryngol Relat Spec 55:216–221

    PubMed  CAS  Google Scholar 

  12. Mansouri K, Shaarawy T, Wedrich A, Mermoud A (2006) Comparing polymethylmethacrylate implant with collagen implant in deep sclerectomy: a randomized controlled trial. J Glaucoma 15:264–270

    Article  PubMed  Google Scholar 

  13. Nguyen C, Boldea RC, Roy S, Schaarawy T, Uffer S, Mermoud A (2006) Outflow mechanisms after deep sclerectomy with two different designs of collagen implant in an animal model. Graefes Arch Clin Exp Ophthalmol 244:1659–1667

    Article  PubMed  CAS  Google Scholar 

  14. Mermoud A, Baerveld G, Minckler DS, Lee MB, Rao NA (1995) Measurement of rabbit intraocular pressure with the Tonopen. Ophthalmologica 9:275–277

    Article  Google Scholar 

  15. Tello C, Liebmann J, Potash SD, Cohen H, Ritch R (1994) Measurement of biomicroscopy images: intraobserver reliability. Invest Ophthalmol Vis Sci 35:3549–3552

    PubMed  CAS  Google Scholar 

  16. Delarive T, Mermoud A, Uffer S, Rossier A (2003) Histological findings of deep sclerectomy with collagen implant in an animal model. Br J Ophthalmol 87:1340–1344

    Article  PubMed  CAS  Google Scholar 

  17. Ethier RC, Chan DW (2001) Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not. Invest Ophthalmol Vis Sci 42:1795–1802

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank M. Tyler Thacher from the Lausanne Swiss Federal Institute of Technology for carefully reading and correcting the paper. The study was supported by the Swiss National Science Foundation, grant # 32–64103.00.

Author information

Authors and Affiliations

  1. Glaucoma Unit, Jules Gonin Eye Hospital, University of Lausanne, Switzerland, Avenue de France 15, CH-1004, Lausanne, Switzerland

    Alessia Basso, Sylvain Roy & André Mermoud

Authors
  1. Alessia Basso
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sylvain Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. André Mermoud
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sylvain Roy.

Additional information

With the financial support of the Swiss National Science Foundation N° 32–64103.00

Rights and permissions

Reprints and permissions

About this article

Cite this article

Basso, A., Roy, S. & Mermoud, A. Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits. Graefes Arch Clin Exp Ophthalmol 246, 849–855 (2008). https://doi.org/10.1007/s00417-008-0782-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-008-0782-y

Keywords

Search

Navigation