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Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study

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Abstract

Background

To evaluate the distribution of central corneal thickness and its associations in the adult Chinese population.

Methods

The Beijing Eye Study 2006 is a population-based study including 3,251 (73.3%) subjects (aged 45+ years) out of 4,439 subjects who participated in the survey in 2001 and who returned for re-examination. Central corneal thickness (CCT) measurements were performed by slit lamp-based optical coherence tomography.

Results

Central corneal thickness measurement data were available for 3,100 (95.4%) subjects. Mean CCT was 556.2±33.1 μm (median: 553 μm; range: 429–688 μm). In multiple regression analysis, CCT was significantly associated with optic disc area (P = 0.043), urban region (P < 0.001; odds ratio (OR): 4.77; 95% confidence interval (CI): 2.37, 7.17), male gender (P < 0.001; OR: 5.64; 95%CI: 2.57, 8.71), and intraocular pressure measurements (P < 0.001). It was not significantly associated with body weight (P = 0.54) and body height (P = 0.66), age (P = 0.17), and refractive error (P = 0.43). Intraocular pressure (measured by pneumotonometry) increased for each μm central corneal thickness increase by 0.03 mmHg.

Conclusions

In the adult Chinese population, CCT was significantly associated optic disc area, urban region, and male gender. Intraocular pneumotonometric pressure measurements increased for each μm increase in central corneal thickness by 0.03 mmHg. CCT was not associated with age and refractive error.

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Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China

    Haitao Zhang, Liang Xu, Changxi Chen & Jost B. Jonas

  2. Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany

    Jost B. Jonas

Authors
  1. Haitao Zhang
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  2. Liang Xu
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  3. Changxi Chen
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  4. Jost B. Jonas
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Corresponding author

Correspondence to Liang Xu.

Additional information

Supported by Beijing Natural Science Foundation No 7071003, Beijing, China.

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Zhang, H., Xu, L., Chen, C. et al. Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study. Graefes Arch Clin Exp Ophthalmol 246, 587–592 (2008). https://doi.org/10.1007/s00417-007-0760-9

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  • DOI: https://doi.org/10.1007/s00417-007-0760-9

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