Bilateral cystoid macular edema in a patient with chronic myeloid leukaemia under treatment with imanitib mesylate: report of an unusual side effect

  • Ilias Georgalas
  • Carlos Pavesio
  • Eric Ezra
Letter to the Editor

Dear Editor:

Imanitib mesylate is a selective inhibitor of the BCR-ABL tyrosine kinase and has been used as an effective therapy for chronic myeloid leukaemia(CML) [1]. The most common ocular side effects of imanitib are periorbital edema and epifora [2]. We report a patient who developed severe bilateral cystoid macular edema (CME) during treatment with imanitib.

A 74-year-old female was referred for cataract surgery in her right eye. She gave a 2-year history of CML, under treatment with injections of interferon. Best-corrected visual acuity (BCVA) was 6/12 right and 6/9 left eye. Fundoscopy of both eyes was unremarkable. Right uncomplicated phacoemulsification was performed in May 2004, and 3 weeks postoperatively the BCVA of the right eye was 6/9+2. It was around this time that therapy for her CML was switched to imatinib 600 mg/day.

One month later the patient complained of epifora and gradual deterioration of vision in both eyes. Her BCVAs were 6/36 right and 6/24 left eye, with...


Imatinib Optical Coherence Tomography Chronic Myeloid Leukaemia Mesylate Acetazolamide 
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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Moorfields Eye HospitalLondonUK

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