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Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin

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Abstract

Purpose

To report on the clinical features of three cases of polypoidal choroidal vasculopathy (PCV) during long-term follow-up after photodynamic therapy (PDT).

Design

Interventional case reports.

Methods

Among the participants in the Japanese Age-Related Macular Degeneration Trial (JAT) at our hospital, a PCV was seen in three eyes at baseline on retrospective analysis of indocyanine green angiography (ICGA) using fundus camera. We report the clinical features of these cases during more than 4 years follow-up.

Results

The mean number of PDT treatments was 5.7. Improved visual acuity (VA) and cessation of fluorescein leakage was achieved within 18 months in all eyes; however, subretinal hemorrhage and subfoveal fluid recurred due to new or recurrent PCV. The final VA decreased markedly in two eyes.

Conclusions

The eyes with PCV, which had been treated successfully with PDT, may have developed new or recurrent PCV during long-term follow-up. Periodical ICGA would be needed to detect abnormal choroidal vascular changes.

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Acknowledgments

Vertepofin (Visudyne) was provided by Novartis Ophthalmics (Bulach, Switzerland) and QLT Inc (Vancouver, BC, Canada).

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Medical School, Room E7, 2-2 Yamadaoka, 565-0871, Suita, Japan

    Kaori Sayanagi, Fumi Gomi, Miki Sawa, Masahito Ohji & Yasuo Tano

Authors
  1. Kaori Sayanagi
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  2. Fumi Gomi
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  3. Miki Sawa
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  4. Masahito Ohji
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  5. Yasuo Tano
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Corresponding author

Correspondence to Fumi Gomi.

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The authors have no proprietary interest in any aspect of this report.

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Sayanagi, K., Gomi, F., Sawa, M. et al. Long-term follow-up of polypoidal choroidal vasculopathy after photodynamic therapy with verteporfin. Graefes Arch Clin Exp Ophthalmol 245, 1569–1571 (2007). https://doi.org/10.1007/s00417-007-0582-9

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  • DOI: https://doi.org/10.1007/s00417-007-0582-9

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