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Conjunctival nodules associated with Vogt-Koyanagi-Harada disease

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Abstract

Background

To report on conjunctival nodules as an unusual manifestation of Vogt-Koyanagi-Harada disease.

Methods

A 24-year-old woman presented with a two-month history of bilateral conjunctival injection and gradually decreased vision. Ophthalmological examinations revealed bilateral granulomatous uveitis and bulbar conjunctival nodules, and a biopsy of the conjunctival nodules was performed.

Results

The biopsy specimens showed noncaseating granulomas. The major components of the infiltrating lymphocytes were CD8-positive T cells. Topical corticosteroid therapy reduced the anterior segment inflammation, and the conjunctival nodules disappeared within a week. Afterwards, the patient demonstrated bilateral retinal detachments, sunset glow fundus and alopecia, and, therefore, was diagnosed to have Vogt-Koyanagi-Harada disease four months after the first symptoms.

Conclusions

Conjunctival nodules may represent the primary manifestation of Vogt-Koyanagi-Harada disease.

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Authors and Affiliations

  1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Kumiko Nakao, Yuka Shimonagano, Norihito Doi & Taiji Sakamoto

Authors
  1. Kumiko Nakao
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  2. Yuka Shimonagano
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  3. Norihito Doi
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  4. Taiji Sakamoto
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Corresponding author

Correspondence to Kumiko Nakao.

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Financial disclosure: none.

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Nakao, K., Shimonagano, Y., Doi, N. et al. Conjunctival nodules associated with Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol 245, 1383–1386 (2007). https://doi.org/10.1007/s00417-007-0540-6

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  • DOI: https://doi.org/10.1007/s00417-007-0540-6

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