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Confocal microscopy imaging of the cornea in patients with silicone oil in the anterior chamber after vitreoretinal surgery

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Abstract

Objective

Evaluation of corneal morphology by confocal microscopy after vitreoretinal surgery complicated by passage of silicone oil into the anterior chamber.

Design

Case series (case control study).

Methods

Eight patients (eight eyes) who had undergone vitreoretinal surgery and had silicone oil in the anterior chamber but no clinically evident corneal abnormalities made up the patient group. The control group consisted of eight patients (eight eyes) who had undergone vitreoretinal surgery with application of silicone oil tamponade but who had no silicone oil clinically observable in the anterior chamber. In vivo examination of the cornea using a ConfoScan 3 (Nidek Technologies) confocal microscope equipped with the standard 40× immersion lens was performed. Central, upper, and lower parts of the cornea were assessed separately. High-magnification evaluation of the status of corneal layers and endothelial cell density in upper parts of the cornea directly in contact with silicone oil in the anterior chamber and in parts of the cornea not in direct contact with silicone oil was carried out.

Results

Alterations in corneal morphology, especially in endothelium and posterior and medium stroma, were observed. In all cases, changes were more advanced in the upper part of the cornea. Endothelial cell density was significantly decreased in upper parts of the cornea.

Conclusions

In patients with silicone oil in the anterior chamber, confocal microscopy imaging reveals early morphological alterations of the cornea before their clinical manifestation.

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References

  1. Ando F (1987) Usefulness and limit of silicone in management of complicated retinal detachment. Jpn J Ophthalmol 31(1):138–146

    PubMed  CAS  Google Scholar 

  2. Azuara-Blanco A, Dua HS, Pillai CT (1999) Pseudo-endothelial dystrophy associated with emulsified silicone oil. Cornea 18:493–494

    Article  PubMed  CAS  Google Scholar 

  3. Beekhuis WH, Ando F, Zivojnovic R, Mertens DA, Peperkamp E. (1987) Basal iridectomy at 6 o’clock in the aphakic eye treated with silicone oil: prevention of keratopathy and secondary glaucoma. Br J Ophthalmol 71(3):197–200

    PubMed  CAS  Google Scholar 

  4. Bohnke M, Masters BR (1997) Long-term contact lens wear induces a corneal degeneration with microdot deposits in the corneal stroma. Ophthalmology 104 (11):1887–1896

    PubMed  CAS  Google Scholar 

  5. Friberg TR, Doran DL, Lazenby FL (1984) The effect of vitreous and retinal surgery on corneal endothelial cell density. Ophthalmology 91:1166–1169

    PubMed  CAS  Google Scholar 

  6. Green K, Cheeks L, Stewart DA, Trask D (1992) Role of toxic ingredients in silicone oils in the induction of increased corneal endothelial permeability. Lens Eye Toxic Res 9(3–4):377–384

    PubMed  CAS  Google Scholar 

  7. Gurelik G, Safak N, Koksal M, Bilgihan K, Hasanreisoglu B (1999) Acute corneal decompensation after silicone oil removal. Int Ophthalmol 23:131–135

    Article  PubMed  CAS  Google Scholar 

  8. Krachmer JH, Mannis MJ, Holland EJ (2005) Cornea, 2nd edn. PA Elsevier Mosby Elsevier Inc, Philadelphia 266:893–894

  9. Lucke K, Laqua H (1990) Silicone oil in the treatment of complicated retinal detachments. Springer-Verlag, Berlin pp 67–70

    Google Scholar 

  10. Mastropasqua L, Nubile M (2002) Confocal microscopy of the cornea. SLACK Inc, Thorofare, NJ pp 54–55

    Google Scholar 

  11. Norman BC, Oliver J, Cheeks L, Hull DS, Birnbaum D, Green K (1990) Corneal endothelium permeability after anterior chamber silicone oil. Ophthalmology 97:29–37

    Google Scholar 

  12. Yagoubi MI, Armitage WJ, Diamond J, Easty DL (1994) Effects of irrigation solutions on corneal endothelial function. Br J Ophthalmol 78:302–306

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland

    Jacek P. Szaflik & Maria Kmera-Muszyńska

  2. Al. Wojska Polskiego 39, 05-520, Konstancin-Jeziorna, Poland

    Jacek P. Szaflik

Authors
  1. Jacek P. Szaflik
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  2. Maria Kmera-Muszyńska
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Corresponding author

Correspondence to Jacek P. Szaflik.

Additional information

The authors have no financial or other interest in any products used or described in this study. No financial support was received.

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Szaflik, J.P., Kmera-Muszyńska, M. Confocal microscopy imaging of the cornea in patients with silicone oil in the anterior chamber after vitreoretinal surgery. Graefe's Arch Clin Exp Ophthalmol 245, 210–214 (2007). https://doi.org/10.1007/s00417-006-0433-0

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  • DOI: https://doi.org/10.1007/s00417-006-0433-0

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