Skip to main content

Advertisement

SpringerLink
Log in

Correlation between optical coherence tomography and autofluorescence in acute posterior multifocal placoid pigment epitheliopathy

  • Perspective
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To report a case of bilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) evaluated by optical coherence tomography (OCT), fundus autofluorescence (AF) and microperimetry, both in the acute phase and after resolution of symptoms.

Methods

Complete ophthalmological evaluation, including fluorescein angiography, OCT, AF, and microperimetry upon presentation and 1 month later, after lesions have subsided. An attempt to correlate the findings on presentation and changes after resolution is performed using the results of these new investigational techniques.

Results

APMPPE showed hyperreflectance in OCT at the level of the outer retinal layers, without increase in retinal thickness. AF revealed early decreased fluorescence due to a masking effect, and later reveals increased fluorescence after resolution of OCT findings. Function is disturbed at the lesion sites, as shown by microperimetry, and later returns to near normal values on microperimetry.

Conclusion

APMPPE shows outer retinal layers changes on OCT, which resolve totally after subsidence of the acute phase. AF shows areas of increased fluorescence after resolution, with near normal return of function on microperimetry.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Deutman AF, Oosterhuis JA, Boen-Tan TN, Aan de Kerk AL (1972) Acute posterior multifocal placoid pigment epitheliopathy; pigment epitheliopathy or choriocapillaritis. Br J Ophthalmol 56:863–874

    Article  PubMed  CAS  Google Scholar 

  2. Deutman AF, Lion F (1977) Choriocapillaris nonperfusion in acute multifocal placoid pigment epitheliopathy. Am J Ophthalmol 84:652–657

    PubMed  CAS  Google Scholar 

  3. Dhaliwal RS, Maguire AM, Flower RW, Arribas NP (1993) Acute posterior multifocal placoid pigment epitheliopathy; an indocyanine green angiographic study. Retina 13:317–325

    Article  PubMed  CAS  Google Scholar 

  4. Framme C, Brinkmann R, Birngruber R, Roider J (2002) Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study. Br J Ophthalmol 86(10):1099–1106

    Article  PubMed  CAS  Google Scholar 

  5. Gass JD (1999) Stereoscopic atlas of macular diseases, 2nd edn. Mosby, St Louis

  6. Young NJA, Bird AC, Sehmi K (1980) Pigment epithelial diseases with abnormal choroidal perfusion. Am J Ophthalmol 90:607–618

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ophthalmology Department, University of Regensburg, Regensburg, Germany

    Ahmed A. R. Souka, Jost Hillenkamp, Felix Gora, Veit-Peter Gabel & Carsten Framme

  2. Ophthalmology Department, University of Alexandria, Alexandria, Egypt

    Ahmed A. R. Souka

  3. University Eye Hospital Regensburg, Franz-Josef-Strauss-Allee 11, D-93042, Regensburg, Germany

    Carsten Framme

Authors
  1. Ahmed A. R. Souka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jost Hillenkamp
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Felix Gora
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Veit-Peter Gabel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carsten Framme
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carsten Framme.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Souka, A.A.R., Hillenkamp, J., Gora, F. et al. Correlation between optical coherence tomography and autofluorescence in acute posterior multifocal placoid pigment epitheliopathy. Graefe's Arch Clin Exp Ophthalmo 244, 1219–1223 (2006). https://doi.org/10.1007/s00417-006-0343-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-006-0343-1

Keywords

Search

Navigation