Abstract
Purpose
To describe highly myopic patients in which either the large choroidal veins or arteries were occluded following PDT treatment.
Methods
Demographic features of two highly myopic patients in which large choroidal vessels were occluded at 1 week following PDT, among a total of 23 patients who received PDT due to choroidal neovascularization (CNV) caused by high myopia, were demonstrated.
Results
In case 1, ICG angiography demonstrated the complete occlusion of several large choroidal veins within the laser-applied area at 1 week after PDT. In case 2, ICG angiography demonstrated an occlusion of choroidal artery emanating from beneath the CNV. One month after PDT, re-perfusion of the occluded choroidal vessels was noted in both patients.
Conclusion
Occlusion of choroidal veins has never been reported in eyes with CNV treated by verteporfin therapy. Although further studies are necessary, occlusion of large choroidal vessels might happen in highly myopic eyes more commonly than expected. ICG angiography at 1 week after PDT was useful to evaluate the impact of PDT on large choroidal vessels.
Similar content being viewed by others
References
Coscas F, Stanescu D, Souied E, Coscas G, Soubrane G (2004) SLO ICG analysis of choroidal changes after multiple (more than three) re-treatment sessions with PDT verteporfin of CNV in AMD. ARVO abstract (#3165)
Klais CM, Ober MD, Freund KB, Ginsburg LH, Luckie A, Mauget-Faysse M, Coscas G, Gross NE, Yannuzzi LA (2005) Choroidal infarction following photodynamic therapy with verteporfin. Arch Ophthalmol 123:1149–1153
Lai TYY, Chan WM, Lam DSC (2004) Transient reduction in retinal function revealed by multifocal electroretinogram after photodynamic therapy. Am J Ophthalmol 137:826–833
Lam DSC, Chan WM, Liu DTL, Fan DSP, Lai WW, Chong KKL (2004) Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization of pathologic myopia in Chinese eyes: a prospective series of 1 and 2 year follow up. Br J Ophthalmol 88:1315–1319
Quaranta M, Arnold J, Coscas G, Francais C, Quentel G, Kuhn D, Soubrane G (1996) Indocyanine green angiographic features of pathologic myopia. Am J Ophthalmol 122:663–671
Schlotzer-Schrehardt U, Viestenz A, Naumann GOH, Laqua H, Michels S, Schmidt-Erfurth U (2002) Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes. Graefe’s Arch Clin Exp Ophthalmol 240:748–757
Schmidt-Erfurth U, Niemeyer M, Geitzenauer W, Michels S (2005) Time course and morphology of vascular effects associated with photodynamic therapy. Ophthalmology 112:2061–2069
Stur M, Ansari-Shahrezaei S (2001) The effect of axial length on laser spot size and laser irradiance. Arch Ophthalmol 119:1323–1328
Verteporfin in Photodynamic Therapy (VIP) Study Group (2003) Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia. 2-year results of a randomized clinical trial-VIP report no. 3. Ophthalmology 110:667–673
Author information
Authors and Affiliations
Corresponding author
Additional information
This study was in part supported by 17591823 and 16390495 from Japan Society for Promotion of Science.
Rights and permissions
About this article
Cite this article
Ohno-Matsui, K., Moriyama, M., Hayashi, K. et al. Choroidal vein and artery occlusion following photodynamic therapy in eyes with pathologic myopia. Graefe's Arch Clin Exp Ophthalmo 244, 1363–1366 (2006). https://doi.org/10.1007/s00417-006-0303-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-006-0303-9