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Effect of posterior capsular opacification removal on scanning laser polarimetry measurements

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To evaluate the effect of posterior capsular opacification (PCO) on retinal nerve fiber layer (RNFL) retardation measurements obtained during scanning laser polarimetry (SLP). We are unaware of previous studies undertaken in this sense.

Methods

SLP was performed using GDx variable corneal compensation (VCC) on 28 eyes of 28 non-glaucomatous patients with clinically significant PCO, previous uneventful cataract surgery and no other ocular pathology, both before and after Nd:YAG capsulotomy. Best-corrected visual acuity (BCVA), intraocular pressure (IOP) and SLP examination parameters prior and following PCO removal were compared using the Student t-test and Wilcoxon’s test. Spearman correlations between BCVA and SLP measurements before and after capsulotomy were also performed.

Results

PCO removal was associated with an increase of BCVA (P<0.0001), nerve fiber indicator (NFI) (P<0.0001) and typical scan score (TSS) (P<0.0001). In parallel, significant decreases of all absolute parameters were observed after capsulotomy. IOP, symmetry, superior ratio, inferior ratio and temporal-superior-nasal-inferior-temporal (TSNIT) standard deviation (SD) revealed no changes. Before capsulotomy, marked correlation existed between the BCVA and some SLP measurements such as nasal average (r= −0.703; P<0.0001) or NFI (r= 0.564; P=0.0017). After PCO removal these correlations were no longer found.

Conclusions

PCO removal changes SLP measurements. Therefore, new measurements to serve as a baseline for future comparisons should be obtained after Nd:YAG capsulotomy. Furthermore, some SLP measurements were significantly associated with BCVA before capsulotomy, suggesting that this technology may be useful to quantify PCO degree in non-glaucomatous patients.

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References

  1. Bagga H, Greenfield DS, Knighton RW (2003) Scanning laser polarimetry with variable corneal compensation: identification and correction for corneal birefringence in eyes with macular disease. Invest Ophthalmol Vis Sci 44:1969–1976

    Article  PubMed  Google Scholar 

  2. Bagga H, Greenfield DS (2005) Quantitative assessment of atypical birefringence images using scanning laser polarimetry with variable corneal compensation. Am J Ophthalmol 139:437–446

    Article  PubMed  Google Scholar 

  3. Bozkurt B, Irkec M, Gedik S, Orhan M, Erdener U, Tatlipinar S, Karaagaoglu E (2002) Effect of peripapillary chorioretinal atrophy on GDx parameters in patients with degenerative myopia. Clin Exp Ophthalmol 30:411–414

    Article  Google Scholar 

  4. Buehl W, Sacu S, Findl O (2005) Association between intensity of posterior capsule opacification and visual acuity. J Cataract Refract Surg 31:543–547

    Article  PubMed  Google Scholar 

  5. Chiba T, Kogure S, Tsukahara S (2000) Influence of cataract on scanning laser polarimetry. Nippon Ganka Gakkai ZasshiFActa Soc Ophthalmol Jpn 104:626–630

    CAS  Google Scholar 

  6. Chiba T, Kogure S, Tsukahara S (2000) Influence of cataract on scanning laser polarimetry. J Ophthalmol 45:202–203

    Google Scholar 

  7. Choplin NT, Lundy DC (2001) The sensitivity and specificity of scanning laser polarimetry in the detection of glaucoma in a clinical setting. Ophthalmology 108:899–904

    Article  PubMed  CAS  Google Scholar 

  8. Colen TP, Tjon-FO-Sang MJ, Mulder PG, Lemij HG (2000) Reproducibility of measurements of the nerve fiber analyzer (NFA/GDx). J Glaucoma 9:363–370

    PubMed  CAS  Google Scholar 

  9. Collur S, Carroll AM, Cameron BD (2000) Human lens effect on in vivo scanning laser polarimetric measurements of retinal nerve fiber layer thickness. Ophthalmic Surg Lasers 31:126–130

    PubMed  CAS  Google Scholar 

  10. Da Pozzo S, Marchesan R, Canziani T, Vattovani O, Ravalico G (2005) A typical pattern of retardation on GDx-VCC and its effect on retinal nerve fibre layer evaluation in glaucomatous eyes. Eye DOI 10.1038/sj.eye.6701997

  11. Garcia-Medina JJ, Garcia-Medina M, Arbona-Nadal MT, Pinazo-Duran MD (2005) Effect of posterior capsular opacification removal on automated perimetry. Eye DOI 10.1038/sj.eye.6701918

  12. Garcia-Medina JJ, Garcia-Medina M, Shahin M, Pinazo-Duran MD (2005) Posterior capsular opacification affects scanning laser polarimetry examination. Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-005-0099-z

  13. Gazzard G, Foster PJ, Devereux JG, Oen F, Chew PT, Khaw PT, Seah SK (2004) Effect of cataract extraction and intraocular lens implantation on nerve fibre layer thickness measurements by scanning laser polarimeter (GDx) in glaucoma patients. Eye 18:163–168

    Article  PubMed  CAS  Google Scholar 

  14. Hayashi K, Hayashi H, Nakao F, Hayashi F (2001) Effect of cataract surgery on intraocular pressure control in glaucoma patients. J Cataract Refract Surg 27:1779–1786

    Article  PubMed  CAS  Google Scholar 

  15. Hayashi K, Hayashi H, Nakao F, Hayashi F (2003) Correlation between posterior capsule opacification and visual function before and after neodymium:YAG laser posterior capsulotomy. Am J Ophthalmol 136:720–726

    Article  PubMed  Google Scholar 

  16. Hollo G (1999) Factors affecting image acquisition during scanning laser polarimetry. Ophthalmic Surg Lasers 29:545–551

    Google Scholar 

  17. Jose RM, Bender LE, Boyce JF, Heatley C (2005) Correlation between the measurement of posterior capsule opacification severity and visual function testing. J Cataract Refract Surg 31:534–542

    Article  PubMed  Google Scholar 

  18. Keates RH, Steinert RF, Puliafito CA, Maxwell SK (1984) Long term follow-up of Nd: YAG capsulotomy. J Am Intraocul Implant Soc 10:164–168

    PubMed  CAS  Google Scholar 

  19. Kim DD, Doyle W, Smith F (1999) Intraocular pressure reduction following phacoemulsification cataract extraction with posterior chamber lens implantation in glaucoma patients. Ophthalmic Surg Lasers 30:37–40

    PubMed  CAS  Google Scholar 

  20. Kook MS, Sung K, Park RH, Kim KR, Kim ST, Kang W (2001) Reproducibility of scanning laser polarimetry (GDx) of peripapillary retinal nerve fiber layer thickness in normal subjects. Graefes Arch Clin Exp Ophthalmol 239:118–121

    PubMed  CAS  Google Scholar 

  21. Kremmer S, Pflug A, Heiligenhaus A, Fanihagh F, Steuhl KP (1999) Laser scanning topography and polarimetry with implantation of intraocular lenses before and after cataract surgery. Klin Monatsbl Augenheilk 214:378–385

    Article  CAS  Google Scholar 

  22. Kremmer S, Garway Heath DF, De Cilla S, Steuhl KP, Selbach JM (2003) Influence of cataract surgery with implantation of different intraocular lenses on scanning laser tomography and polarimetry. Am J Ophthalmol 136:1016–1021

    Article  PubMed  Google Scholar 

  23. Lerman S, Thrasher B, Moran M (1984) Vitreous changes after neodymium-YAG laser irradiation of the posterior lens capsule or mid-vitreous. Am J Ophthalmol 97:470–475

    PubMed  CAS  Google Scholar 

  24. Moreno-Montanes J, Alvarez A, Maldonado MJ (2005) Objective quantification of posterior capsule opacification after cataract surgery with optical coherence tomography. Invest Ophthalmol Vis Sci 46:3999–4006

    Article  PubMed  Google Scholar 

  25. Park RJ, Chen PP, Karyampudi P, Mills RP, Harrison DA, Kim J (2001) Effects of cataract extraction with intraocular lens placement on scanning laser polarimetry of the peripapillary nerve fiber layer. Am J Ophthalmol 132:507–511

    Article  PubMed  CAS  Google Scholar 

  26. Pons ME, Rothman RF, Ordez RG, Liebmann JM, Ritch R (2001) Vitreous opacities affect scanning laser polarimetry measurements. Am J Ophthalmol 131:511–513

    Article  PubMed  CAS  Google Scholar 

  27. Quigley HA, Katz J, Derick RJ, Gilbert D, Sommer A (1992) An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology 99:19–28

    PubMed  CAS  Google Scholar 

  28. Reus NJ, Lemij HG (2004) Diagnostic Accuracy of the GDx VCC for Glaucoma. Ophthalmology 111:1860–1865

    Article  PubMed  Google Scholar 

  29. Rhee DJ, Greenfield DS, Chen PP, Schiffman J (2002) Reproducibility of retinal nerve fiber layer thickness measurements using scanning laser polarimetry in pseudophakic eyes. Ophthalmic Surg Lasers 33:117–122

    PubMed  Google Scholar 

  30. Schaumberg DA, Dana MR, Christen WG, Glynn RJ (1988) A systematic overview of the incidence of posterior capsule opacification. Ophthalmology 105:1213–1221

    Article  Google Scholar 

  31. Sebag J (1987) Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol 225:89–93

    Article  PubMed  CAS  Google Scholar 

  32. Shin DH, Vandenbelt SM, Kim PH, Gross JP, Keole NS, Lee SH, Birt CM, Reed SY (2002) Comparison of long-term incidence of posterior capsular opacification between phacoemulsification and phacotrabeculectomy. Am J Ophthalmol 133:40–47

    Article  PubMed  Google Scholar 

  33. Shingleton BJ, Gamell LS, O’Donoghue MW, Baylus SL, King R (1999) Long-term changes in intraocular pressure after clear corneal phacoemulsification: normal patients versus glaucoma suspect and glaucoma patients. J Cataract Refract Surg 25:885–890

    Article  PubMed  CAS  Google Scholar 

  34. Sommer A, Katz J, Quigley HA, Millar NR, Robin AL, Richter RC, Witt KA (1991) Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 109:77–83

    PubMed  CAS  Google Scholar 

  35. Tong JT, Miller KM (1988) Intraocular pressure change after sutureless phacoemulsification and foldable posterior chamber lens implantation. J Cataract Refract Surg 24:256–262

    Google Scholar 

  36. Toth M, Hollo G (2005) Enhanced corneal compensation for scanning laser polarimetry on eyes with atypical polarisation pattern. Br J Ophthalmol 89:1139–1142

    Article  PubMed  CAS  Google Scholar 

  37. Tuulonen A, Lehtola J, Airaksinen PJ (1993). Nerve fiber layer defects with normal visual fields. Do normal optic disc and normal visual field indicate absence of glaucomatous abnormality? Ophthalmology 100:587–597

    PubMed  CAS  Google Scholar 

  38. Vetrugno M, Trabucco T, Sisto D, Sborgia C (2004) Effect of cataract surgery and foldable intraocular lens implantation on retinal nerve fiber layer as measured by scanning laser polarimetry with variable corneal compensator. Eur J Ophthalmol 14:106–110

    PubMed  CAS  Google Scholar 

  39. Weinreb RN, Dreher AW, Coleman A, Quigley H, Shaw B, Reiter K (1990) Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness. Arch Ophthalmol 108:557–560

    PubMed  CAS  Google Scholar 

  40. Weinreb RN, Zangwill L, Berry CC, Bathija R, Sample PA (1998) Detection of glaucoma with scanning laser polarimetry. Arch Ophthalmol 116:1583–1589

    PubMed  CAS  Google Scholar 

  41. Weinreb RN, Bowd C, Zangwill LM (2003) Glaucoma detection using scanning laser polarimetry with variable corneal polarization compensation. Arch Ophthalmol 121:218–224

    PubMed  Google Scholar 

  42. Zhou Q, Knighton RW (1997) Light scattering and form birefringence of parallel cylindrical arrays that represent cellular organelles of the retinal nerve fiber layer. Appl Opt 36:2273–2285

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

The authors thank Dr. José Sánchez for the statistical revision of data presented in this study.

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Authors and Affiliations

  1. Ophthalmology Research Unit “Santiago Grisolia” Department of Ophthalmology, University Hospital Doctor Peset, Avenida Gaspar Aguilar, 90, 46017, Valencia, Spain

    José Javier García-Medina, Samuel González-Ocampo Dorta, María Dolores Pinazo-Durán, Roberto Gallego-Pinazo & Vicente Calixto Zanón-Moreno

  2. Department of Ophthalmology, Hospital La Inmaculada, Avenida Dra. Ana Parra s/n, 04600, Huercal-Overa, Almería, Spain

    José Javier García-Medina

  3. Department of Ophthalmology, Torrecárdenas Hospital, Paraje Torrecárdenas s/n, 04009, Almería, Spain

    Manuel García-Medina

  4. Department of Ophthalmology, Punta de Europa Hospital, Algeciras, Cádiz, Spain

    María Dolores Pinazo-Durán

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  1. José Javier García-Medina
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  2. Manuel García-Medina
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Correspondence to José Javier García-Medina.

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García-Medina, J.J., García-Medina, M., Dorta, S.GO. et al. Effect of posterior capsular opacification removal on scanning laser polarimetry measurements. Graefe's Arch Clin Exp Ophthalmo 244, 1398–1405 (2006). https://doi.org/10.1007/s00417-005-0244-8

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  • DOI: https://doi.org/10.1007/s00417-005-0244-8

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