Abstract
Background
To report the protracted 9-year survival of a patient after surgical management of multiple liver metastases from uveal melanoma.
Design
Interventional case report.
Methods
A 30-year-old patient, treated for choroidal melanoma by proton beam therapy, was semiannually followed by abdominal ultrasonography. Two years after initial treatment, a total body computed tomography scan suggested the diagnosis of isolated liver metastases.
Results
Multiple wedge resections and postoperative intra-arterial chemotherapy with fotemustine were performed. After 4 years, a metastatic nodule in the head of the pancreas was detected and surgically removed. Eighteen months later, metastases were progressively detected in other organs. The patient finally died of carcinomatous meningitis 9 years of first treatment of metastases.
Conclusions
In the present case, the surgical control of liver metastases associated with intra-arterial chemotherapy prolonged the quality and length of life with progressive disease extension to other organs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aoyama T, Mastrangelo MJ, Berd D, et al (2000) Protracted survival after resection of metastatic uveal melanoma. Cancer 89:1561–1568
Collaborative Ocular Melanoma Study (2001) Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15. Arch Ophthalmol 119:670–676
Fournier GA, Albert DM, Arrigg CA et al. (1984) Resection of solitary metastasis. Approach to palliative treatment of hepatic involvement with choroidal melanoma. Arch Ophthalmol 102:80–82
Gragoudas ES, Egan KM, Seddon JM et al. (1991) Survival of patients with metastases from uveal melanoma. Ophthalmology 98:383–389; discussion 390
Gunduz K, Shields JA, Shields CL, Sato T, Mastrangelo MJ (1998) Surgical removal of solitary hepatic metastasis from choroidal melanoma. Am J Ophthalmol 125:407–409
Hsueh E, Essner R, Foshag L et al. (2004) Prolonged survival after complete resection of metastases from intraocular melanoma. Cancer 100:122–129
Kath R, Hayungs J, Bornfeld N et al. (1993) Prognosis and treatment of disseminated uveal melanoma. Cancer 72:2219–2223
Pyrhonen S (1998) The treatment of metastatic uveal melanoma. Eur J Cancer 34(Suppl 3):S27–S30
Rajpal S, Moore R, Karakousis CP (1983) Survival in metastatic ocular melanoma. Cancer 52:334–336
Rivoire M, Kodjikian L, Negrier S (2004) Prolonged survival after complete resection of metastases from intraocular melanoma. Cancer 101:207–208
Salmon RJ, Levy C, Plancher C et al. (1998) Treatment of liver metastases from uveal melanoma by combined surgery–chemotherapy. Eur J Surg Oncol 24:127–130
Author information
Authors and Affiliations
Corresponding author
Additional information
This study received no funding, and the authors had no financial or proprietary interest in it. Laurent Kodjikian and Michel Rivoire have full access to all available data and take full responsibility for its integrity and for the accuracy of the analysis. The authors agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review the data if requested.
Rights and permissions
About this article
Cite this article
Kodjikian, L., Grange, JD. & Rivoire, M. Prolonged survival after resection of liver metastases from uveal melanoma and intra-arterial chemotherapy. Graefe's Arch Clin Exp Ophthalmol 243, 622–624 (2005). https://doi.org/10.1007/s00417-004-1057-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-004-1057-x