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Effect of bimatoprost on ocular circulation in patients with open-angle glaucoma or ocular hypertension

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To study the effect of bimatoprost 0.03% (Lumigan) on ocular hemodynamics in patients with open-angle glaucoma or ocular hypertension.

Methods

One randomly selected eye of each of 26 patients with open-angle glaucoma or ocular hypertension was enrolled. Each patient received a drop of bimatoprost 0.03% once daily for 1 month. The effect of bimatoprost on ocular circulation was assessed by color Doppler imaging (CDI), which measured peak systolic, end-diastolic blood flow velocities and resistance indices in the ophthalmic, posterior ciliary and central retinal arteries. Retrobulbar hemodynamics by CDI, intraocular pressure by Goldmann applanation tonometer, blood pressure by cuff, and heart rate by palpation were measured at baseline and at 1 month after bimatoprost treatment.

Results

Blood flow velocities and resistance indices in all retrobulbar vessels showed no statistically significant differences between baseline and bimatoprost condition (P>0.05). Bimatoprost lowered intraocular pressure significantly (P<0.001), with a mean change of 6.5 mmHg (27%) after 1 month of treatment. The systolic (P=0.38) and diastolic (P=0.74) blood pressures and pulse rate (P=0.94) did not show statistically significant differences during the study period.

Conclusions

The results of this study suggest that topical bimatoprost 0.03% significantly reduces intraocular pressure in patients with open-angle glaucoma or ocular hypertension. However, it does not have any effect on retrobulbar hemodynamics in open-angle glaucoma and ocular hypertension.

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Authors and Affiliations

  1. Çagdaş Sokak 37/13, 06130, Aydınlıkevler, Ankara, Turkey

    Cengiz Akarsu

  2. Department of Ophthalmology, University of Kırıkkale, Kırıkkale, Turkey

    Cengiz Akarsu, Pelin Taner & Ahmet Ergin

  3. Department of Radiology, University of Kırıkkale, Kırıkkale, Turkey

    Sevda Yılmaz

Authors
  1. Cengiz Akarsu
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  2. Sevda Yılmaz
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  3. Pelin Taner
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  4. Ahmet Ergin
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Correspondence to Cengiz Akarsu.

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The authors have no commercial or proprietary interest in any of the equipment and medication mentioned in this study

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Akarsu, C., Yılmaz, S., Taner, P. et al. Effect of bimatoprost on ocular circulation in patients with open-angle glaucoma or ocular hypertension. Graefe's Arch Clin Exp Ophthalmol 242, 814–818 (2004). https://doi.org/10.1007/s00417-004-0906-y

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  • DOI: https://doi.org/10.1007/s00417-004-0906-y

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