Skip to main content

Advertisement

SpringerLink
Log in

Basement membranes and artificial substrates in cell transplantation

  • Review
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1A–C
Fig. 2A–C
Fig. 3A,B

References

  1. Algvere PV, Berglin L, Gouras P, et al (1997) Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefes Arch Clin Exp Ophthalmol 235:149–158

    CAS  PubMed  Google Scholar 

  2. Algvere PV, Gouras P, Dafgard KE (1999) Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD. Eur J Ophthalmol 9:217–230

    CAS  PubMed  Google Scholar 

  3. Anderson DH, Mullins RF, Hageman GS, et al (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134:411–431

    Article  CAS  PubMed  Google Scholar 

  4. Berger AS, Kaplan HJ (1992) Clinical experience with the surgical removal of subfoveal neovascular membranes. Short-term postoperative results. Ophthalmology 99:969–975

    CAS  PubMed  Google Scholar 

  5. Bhatt NS, Newsome DA, Fenech T, et al (1994) Experimental transplantation of human retinal pigment epithelial cells on collagen substrates. Am J Ophthalmol 117:214–221

    CAS  PubMed  Google Scholar 

  6. Bressler NM, Silva JC, Bressler SB, et al (1994) Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina 14:130–142

    CAS  PubMed  Google Scholar 

  7. Castellarin AA, Sugino IK, Vargas JA, et al (1998) In vitro transplantation of fetal human retinal pigment epithelial cells onto human cadaver Bruch’s membrane. Exp Eye Res 66:49–67

    Article  CAS  PubMed  Google Scholar 

  8. Chacko DM, Rogers JA, Turner JE, et al (2000) Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. Biochem Biophys Res Commun 268:842–846

    Article  CAS  PubMed  Google Scholar 

  9. Crafoord S, Algvere PV, Seregard S, et al (1999) Long-term outcome of RPE allografts to the subretinal space of rabbits. Acta Ophthalmol Scand 77:247–254

    CAS  PubMed  Google Scholar 

  10. Crafoord S, Geng L, Seregard S, et al (2002) Photoreceptor survival in transplantation of autologous iris pigment epithelial cells to the subretinal space. Acta Ophthalmol Scand 80:387–394

    Article  PubMed  Google Scholar 

  11. Durlu YK, Tamai M (1997) Transplantation of retinal pigment epithelium using viable cryopreserved cells. Cell Transplant 6:149–162

    Article  CAS  PubMed  Google Scholar 

  12. Farrokh-Siar L, Rezai KA, Patel SC, et al (1999) Cryoprecipitate: An autologous substrate for human fetal retinal pigment epithelium. Curr Eye Res 19:89–94

    Article  CAS  PubMed  Google Scholar 

  13. Fine SL, Berger JW, Maguire MG, et al (2000) Age-related macular degeneration. N Engl J Med 342:483–492

    Article  CAS  PubMed  Google Scholar 

  14. Gass JD (1973) Drusen and disciform macular detachment and degeneration. Arch Ophthalmol 90:206–217

    CAS  PubMed  Google Scholar 

  15. Giordano GG, Thomson RC, Ishaug SL, et al (1997) Retinal pigment epithelium cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 34:87–93

    Article  CAS  PubMed  Google Scholar 

  16. Gouras P, Du J, Kjeldbye H, et al (1991) Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest Ophthalmol Vis Sci 32:3167–3174

    Google Scholar 

  17. Grierson I, Heathcote L, Hiscott P, et al (2000) Hepatocyte growth factor/scatter factor in the eye. Prog Retin Eye Res 19:779–802

    Article  CAS  PubMed  Google Scholar 

  18. Grossniklaus HE, Hutchinson AK, Capone A Jr, et al (1994) Clinicopathologic features of surgically excised choroidal neovascular membranes. Ophthalmology 101:1099–1111

    CAS  PubMed  Google Scholar 

  19. Hagan S, Hiscott P, Sheridan CM, et al (2003) Effects of the matricellular protein SPARC on human retinal pigment epithelial cell behavior. Mol Vis 9:87–92

    CAS  PubMed  Google Scholar 

  20. Hageman GS, Mullins RF, Clark WG, et al (1995) Drusen share molecular constituents common to atherosclerotic, elastotic and amyloid deposits. Invest Ophthalmol Vis Sci 36:S432

    Google Scholar 

  21. Hageman GS, Mullins RF, Russell SR, et al (1999) Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J 13:477–484

    CAS  PubMed  Google Scholar 

  22. Hageman GS, Luthert PJ, Victor Chong NH, et al (2001) An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE–Bruch’s membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 20:705–732

    Article  CAS  PubMed  Google Scholar 

  23. Hartmann U, Sistani F, Steinhorst UH (1999) Human and porcine anterior lens capsule as support for growing and grafting retinal pigment epithelium and iris pigment epithelium. Graefes Arch Clin Exp Ophthalmol 237:940–945

    Article  CAS  PubMed  Google Scholar 

  24. Hiscott P, Sheridan C, Magee RM, et al (1999) Matrix and the retinal pigment epithelium in proliferative retinal disease. Prog Retin Eye Res 18:167–190

    Article  CAS  PubMed  Google Scholar 

  25. Hiscott P, Hagan S, Heathcote L, et al (2002) Pathobiology of epiretinal and subretinal membranes: possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC). Eye 16:393–403

    Article  CAS  PubMed  Google Scholar 

  26. Hogan MJ (1972) Role of the retinal pigment epithelium in macular disease. Trans Am Acad Ophthalmol Otolaryngol 76:64–80

    CAS  PubMed  Google Scholar 

  27. Holz FG, Wolfensberger TJ, Piguet B, et al (1994) Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology 101:1522–1528

    CAS  PubMed  Google Scholar 

  28. Ishida M, Lui GM, Yamani A, et al (1998) Culture of human retinal pigment epithelial cells from peripheral scleral flap biopsies. Curr Eye Res 17:392–402

    CAS  PubMed  Google Scholar 

  29. Kent D, Sheridan C, Tomkinson HA, et al (2003) Edible mushroom (Agaricus bisporus) lectin modulates human retinal pigment epithelial cell behaviour in vitro. Exp Eye Res 76:213–219

    Article  CAS  PubMed  Google Scholar 

  30. Kent D, Sheridan CM, Tomkinson HA, et al (2003) Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro. Wound Repair Regen 11:285–291

    Article  PubMed  Google Scholar 

  31. Kiilgaard JF, Wiencke AK, Scherfig E, et al (2002) Transplantation of allogenic anterior lens capsule to the subretinal space in pigs. Acta Ophthalmol Scand 80:76–81

    Article  PubMed  Google Scholar 

  32. Killingsworth MC (1987) Age-related components of Bruch’s membrane in the human eye. Graefes Arch Clin Exp Ophthalmol 225:406–412

    CAS  PubMed  Google Scholar 

  33. Klein R, Klein BE, Linton KL, et al (1993) The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking. Am J Epidemiol 137:190–200

    CAS  PubMed  Google Scholar 

  34. Knoernschild T, Grasbon T, Wilsch C, et al (2003) RPE cell transplants to non-immune-privileged sites of the eye transform into fibroblast-like cells. Curr Eye Res 27:25–34

    Article  PubMed  Google Scholar 

  35. Lawrence JM, Sauve Y, Keegan DJ, et al (2000) Schwann cell grafting into the retina of the dystrophic RCS rat limits functional deterioration. Invest Ophthalmol Vis Sci 41:518–528

    CAS  PubMed  Google Scholar 

  36. Li LX, Turner JE (1988) Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. Exp Eye Res 47:911–917

    CAS  PubMed  Google Scholar 

  37. Li LX, Turner JE (1988) Transplantation of retinal pigment epithelial cells to immature and adult rat hosts: short- and long-term survival characteristics. Exp Eye Res 47:771–785

    CAS  PubMed  Google Scholar 

  38. Li L, Turner JE (1991) Optimal conditions for long-term photoreceptor cell rescue in RCS rats: the necessity for healthy RPE transplants. Exp Eye Res 52:669–679

    PubMed  Google Scholar 

  39. Liversidge J, Sewell HF, Thomson AW, et al (1988) Lymphokine-induced MHC class II antigen expression on cultured retinal pigment epithelial cells and the influence of cyclosporin A. Immunology 63:313–317

    CAS  PubMed  Google Scholar 

  40. Lopez PF, Grossniklaus HE, Lambert HM, et al (1991) Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol 112:647–656

    CAS  PubMed  Google Scholar 

  41. Lopez R, Gouras P, Brittis M, et al (1987) Transplantation of cultured rabbit retinal epithelium to rabbit retina using a closed-eye method. Invest Ophthalmol Vis Sci 28:1131–1137

    CAS  PubMed  Google Scholar 

  42. Lopez R, Gouras P, Kjeldbye H, et al (1989) Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest Ophthalmol Vis Sci 30:586–588

    CAS  PubMed  Google Scholar 

  43. Lund RD, Adamson P, Sauve Y, et al (2001) Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proc Natl Acad Sci U S A 98:9942–9947

    Article  CAS  PubMed  Google Scholar 

  44. Lund RD, Kwan AS, Keegan DJ, et al (2001) Cell transplantation as a treatment for retinal disease. Prog Retin Eye Res 20:415–449

    Article  CAS  PubMed  Google Scholar 

  45. Mazure A, Grierson I (1992) In vitro studies of the contractility of cell types involved in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 33:3407–3416

    CAS  PubMed  Google Scholar 

  46. McLaughlin BJ, Fan W, Zheng JJ, et al (2003) Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion. Invest Ophthalmol Vis Sci 44:3669–3674

    Article  PubMed  Google Scholar 

  47. Merrill PT, LoRusso FJ, Lomeo MD, et al (1999) Surgical removal of subfoveal choroidal neovascularization in age-related macular degeneration. Ophthalmology 106:782–789

    Google Scholar 

  48. Miner JH, Patton BL, Lentz SI, et al (1997) The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol 137:685–701

    CAS  PubMed  Google Scholar 

  49. Mohand-Said S, Hicks D, Simonutti M, et al (1997) Photoreceptor transplants increase host cone survival in the retinal degeneration (rd) mouse. Ophthalmic Res 29:290–297

    Google Scholar 

  50. Mullins RF, Aptsiauri N, Hageman GS (2001) Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye 15:390–395

    CAS  PubMed  Google Scholar 

  51. Mullins RF, Russell SR, Anderson DH, et al (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14:835–846

    CAS  PubMed  Google Scholar 

  52. Nasir MA, Sugino I, Zarbin MA (1997) Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration. Br J Ophthalmol 81:481–489

    CAS  PubMed  Google Scholar 

  53. Nicolini J, Kiilgaard JF, Wiencke AK, et al (2000) The anterior lens capsule used as support material in RPE cell-transplantation. Acta Ophthalmol Scand 78:527–531

    Article  CAS  PubMed  Google Scholar 

  54. Oganesian A, Gabrielian K, Ernest JT, et al (1999) A new model of retinal pigment epithelium transplantation with microspheres. Arch Ophthalmol 117:1192–1200

    CAS  PubMed  Google Scholar 

  55. Ormerod LD, Puklin JE, Frank RN (1994) Long-term outcomes after the surgical removal of advanced subfoveal neovascular membranes in age-related macular degeneration. Ophthalmology 101:1201–1210

    CAS  PubMed  Google Scholar 

  56. Pauleikhoff D, Barondes MJ, Minassian D, et al (1990) Drusen as risk factors in age-related macular disease. Am J Ophthalmol 109:38–43

    CAS  PubMed  Google Scholar 

  57. Phillips SJ, Sadda SR, Tso MO, et al (2003) Autologous transplantation of retinal pigment epithelium after mechanical debridement of Bruch’s membrane. Curr Eye Res 26:81–88

    Article  PubMed  Google Scholar 

  58. Pollack JS, Del Priore LV, Smith ME, et al (1996) Postoperative abnormalities of the choriocapillaris in exudative age-related macular degeneration. Br J Ophthalmol 80:314–318

    CAS  PubMed  Google Scholar 

  59. Rezai KA, Semnani RT, Patel SC, et al (1997) The immunogenic potential of human fetal retinal pigment epithelium and its relation to transplantation. Invest Ophthalmol Vis Sci 38:2662–2671

    CAS  PubMed  Google Scholar 

  60. Sarks JP, Sarks SH, Killingsworth MC (1988) Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2:552–577

    PubMed  Google Scholar 

  61. Sarks JP, Sarks SH, Killingsworth MC (1997) Morphology of early choroidal neovascularisation in age-related macular degeneration: correlation with activity. Eye 11:515–522

    PubMed  Google Scholar 

  62. Sarraf D, Gin T, Yu F, et al (1999) Long-term drusen study. Retina 19:513–519

    CAS  PubMed  Google Scholar 

  63. Schraermeyer U, Kociok N, Heimann K (1999) Rescue effects of IPE transplants in RCS rats: short-term results. Invest Ophthalmol Vis Sci 40:1545–1556

    CAS  PubMed  Google Scholar 

  64. Schraermeyer U, Thumann G, Luther T, et al (2001) Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats. Cell Transplant 10:673–680

    CAS  PubMed  Google Scholar 

  65. Sheedlo HJ, Li L, Turner JE (1993) Effects of RPE age and culture conditions on support of photoreceptor cell survival in transplanted RCS dystrophic rats. Exp Eye Res 57:753–761

    Article  CAS  PubMed  Google Scholar 

  66. Sheridan CM, Hiscott P, Grierson I (2000) The role of glycoproteins and integrins in human RPE-induced collagen matrix contraction. Exp Eye Res 71:S119

    Article  Google Scholar 

  67. Sheridan CM, Hiscott P, Grierson I (2001) The role of thrombospondin 1 in RPE migration and in human RPE induced collagen matrix contraction. Invest Ophthalmol Vis Sci 42:S811

    Google Scholar 

  68. Sheridan CM, Occleston NL, Hiscott P, et al (2001) Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue. Am J Pathol 159:1555–1566

    CAS  PubMed  Google Scholar 

  69. Sheridan CM, Magee RM, Hiscott PS, et al (2002) The role of matricellular proteins thrombospondin-1 and osteonectin during RPE cell migration in proliferative vitreoretinopathy. Curr Eye Res 25:279–285

    Article  PubMed  Google Scholar 

  70. Shiragami C, Matsuo T, Shiraga F, et al (1998) Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch’s membrane in rabbits. Br J Ophthalmol 82:1056–1062

    CAS  PubMed  Google Scholar 

  71. Stone EM, Sheffield VC, Hageman GS (2001) Molecular genetics of age-related macular degeneration. Hum Mol Genet 10:2285–2292

    Article  CAS  PubMed  Google Scholar 

  72. Streilein JW, Ma N, Wenkel H, et al (2002) Immunobiology and privilege of neuronal retina and pigment epithelium transplants. Vision Res 42:487–495

    Article  PubMed  Google Scholar 

  73. Takahashi M, Palmer TD, Takahashi J, et al (1998) Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci 12:340–348

    Article  CAS  PubMed  Google Scholar 

  74. Teeters VW, Bird AC (1973) The development of neovascularization of senile disciform macular degeneration. Am J Ophthalmol 76:1–18

    CAS  PubMed  Google Scholar 

  75. Tezel TH, Del Priore LV (1997) Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol 235:41–47

    CAS  PubMed  Google Scholar 

  76. Tezel TH, Kaplan HJ, Del Priore LV (1999) Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch’s membrane. Invest Ophthalmol Vis Sci 40:467–476

    CAS  PubMed  Google Scholar 

  77. Thomas MA, Dickinson JD, Melberg NS, et al (1994) Visual results after surgical removal of subfoveal choroidal neovascular membranes. Ophthalmology 101:1384–1396

    Google Scholar 

  78. Thumann G, Schraermeyer U, Bartz-Schmidt KU, et al (1997) Descemet’s membrane as membranous support in RPE/IPE transplantation. Curr Eye Res 16:1236–1238

    Article  CAS  PubMed  Google Scholar 

  79. Tsukahara I, Ninomiya S, Castellarin A, et al (2002) Early attachment of uncultured retinal pigment epithelium from aged donors onto Bruch’s membrane explants. Exp Eye Res 74:255–266

    Article  CAS  PubMed  Google Scholar 

  80. Tunggal P, Smyth N, Paulsson M, et al (2000) Laminins: structure and genetic regulation. Microsc Res Tech 51:214–227

    CAS  PubMed  Google Scholar 

  81. Vinding T (1990) Occurrence of drusen, pigmentary changes and exudative changes in the macula with reference to age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Ophthalmol (Copenh) 68:410–414

    Google Scholar 

  82. Wang H, Ninomiya Y, Sugino IK, et al (2003) Retinal pigment epithelium wound healing in human Bruch’s membrane explants. Invest Ophthalmol Vis Sci 44:2199–2210

    Article  PubMed  Google Scholar 

  83. Wenkel H, Streilein JW (1998) Analysis of immune deviation elicited by antigens injected into the subretinal space. Invest Ophthalmol Vis Sci 39:1823–1834

    CAS  PubMed  Google Scholar 

  84. Wilson DJ, Rhodes NP, Williams RL (2003) Surface modification of a segmented polyetherurethane using a low-powered gas plasma and its influence on the activation of the coagulation system. Biomaterials 24:5069–5081

    Article  CAS  PubMed  Google Scholar 

  85. Wong D, Lois N (2000) Foveal relocation by redistribution of the neurosensory retina. Br J Ophthalmol 84:352–357

    Article  CAS  PubMed  Google Scholar 

  86. Zarbin MA (1998) Age-related macular degeneration: review of pathogenesis. Eur J Ophthalmol 8:199–206

    Google Scholar 

  87. Zdrahala RJ, Zdrahala IJ (1999) Biomedical applications of polyurethanes: a review of past promises, present realities, and a vibrant future. J Biomater Appl 14:67–90

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Dunhill Medical Trust; Fight for Sight; the R&D Support Fund of the Royal Liverpool & Broadgreen University Hospitals, and St. Paul’s Foundation for the Prevention of Blindness. Daniel Brotchie provided photographic and manuscript preparation assistance. Matthew Colthurst provided figure drawing.

Author information

Authors and Affiliations

  1. Unit of Ophthalmology, Department of Medicine, University Clinical Departments, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, UK

    Carl Sheridan & Ian Grierson

  2. Department of Clinical Engineering, University Clinical Departments, University of Liverpool, Liverpool, UK

    Rachel Williams

Authors
  1. Carl Sheridan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rachel Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ian Grierson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carl Sheridan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sheridan, C., Williams, R. & Grierson, I. Basement membranes and artificial substrates in cell transplantation. Graefe's Arch Clin Exp Ophthalmol 242, 68–75 (2004). https://doi.org/10.1007/s00417-003-0800-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-003-0800-z

Keywords

Search

Navigation