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Effects of a new dexamethasone-delivery system (Surodex) on experimental intraocular inflammation models

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Abstract

Background

To investigate the effects of a new biodegradable dexamethasone drug delivery system, Surodex, in two experimental intraocular inflammation models; endotoxin-induced uveitis (EIU) and experimental autoimmune uveoretinitis (EAU).

Methods

Surodex was inserted into the right anterior chambers (ACs) of rats. In the EIU experiment, protein concentration, cell infiltration, and myeloperoxidase (MPO) activity in the aqueous humor were measured 24 h after injection. Eyes were evaluated histopathologically. In the EAU experiment, firstly, Surodex was administered at various days after immunization. Then, Surodex was administered on day 9 and eyes were evaluated histopathologically. Intraocular cytokine levels (IFN-γ and IL-4) were investigated.

Results

In the EIU experiments, eyes with Surodex exhibited significantly reduced inflammation compared with contralateral controls. Protein concentrations, cell infiltrations, as well as MPO activity were reduced. In the EAU experiments, all rats with Surodex given on days 0 or 7 showed no or significantly reduced inflammation in both eyes. Rats treated on day 12 developed reduced inflammation only in the treated eyes. IFN-γ levels were significantly lower in the eyes with Surodex, whereas IL-4 was not detectable.

Conclusions

This new, biodegradable corticosteroid drug-delivery system is highly effective in suppressing intraocular inflammation, and should be a useful tool to manage uveitis in humans.

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Acknowledgement. We sincerely thank Y. Ishii for his excellent preparation of histopathological specimens.

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Author notes

  1. Masuhiro Kodama

    Present address: Department of Ophthalmology, Musashino Red Cross Hospital, 1-26-1 Kyonanchou, Musashino-shi, 180-8610, Tokyo, Japan

Authors and Affiliations

  1. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Masuhiro Kodama, Jiro Numaga, Atsushi Yoshida, Toshikatsu Kaburaki, Yujiro Fujino & Hidetoshi Kawashima

  2. Doheny Eye Institute, University of Southern California, Los Angeles, CA, USA

    Jiro Numaga, Guey-Shuang Wu & Narsing A. Rao

  3. Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

    Tetsuro Oshika

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  1. Masuhiro Kodama
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  2. Jiro Numaga
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  9. Hidetoshi Kawashima
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Correspondence to Masuhiro Kodama.

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Kodama, M., Numaga, J., Yoshida, A. et al. Effects of a new dexamethasone-delivery system (Surodex) on experimental intraocular inflammation models. Graefe's Arch Clin Exp Ophthalmol 241, 927–933 (2003). https://doi.org/10.1007/s00417-003-0753-2

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  • DOI: https://doi.org/10.1007/s00417-003-0753-2

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